PDF(Pubmed)
Abstract：
We investigated the associations of low handgrip strength (HGS, i.e., a marker of muscular fitness) with liver fat content (LFC) and serum liver enzymes in a population-based setting. We used data from 2700 participants (51.7% women), aged 21-90 years, from two independent cohorts of the population-based Study of Health in Pomerania (SHIP-START-2 and SHIP-TREND-0). Cross-sectional, multivariable adjusted regression models were performed to examine the associations of HGS with LFC, measured by magnetic resonance imaging and serum liver enzymes. We found significant inverse associations of HGS with both LFC and serum liver enzymes. Specifically, a 10-kg lower HGS was associated with a 0.59% (95% confidence interval [CI]: 0.24-0.94; p = 0.001) higher LFC, a 0.051 µkatal/L (95% CI: 0.005-0.097; p = 0.031) higher gamma-glutamyltransferase (GGT) concentration and a 0.010 µkatal/L (95% CI: 0.001-0.020; p = 0.023) higher aspartate aminotransferase (AST) concentration. The adjusted odds-ratio for prevalent hepatic steatosis (defined by a MRI-PDFF ≥5.1%) per 10-kg lower HGS was 1.21 (95% CI: 1.04-1.40; p = 0.014). When considering only obese individuals, those with low HGS had a 1.58% (95% CI: 0.18-2.98; p = 0.027) higher mean LFC and higher chance of prevalent hepatic steatosis (adjusted OR 1.74, 95% CI: 1.15-2.62; p = 0.009) compared to individuals with high HGS. We found similar associations in individuals with overweight, but not in those with normal weight. Lower HGS was strongly associated with both higher LFC and higher serum GGT and AST concentrations. Future studies might clarify whether these findings reflect adverse effects of a sedentary lifestyle or aging on the liver.
摘要：
我们调查了低握力的关联(HGS，即，肌肉适应性的标志）在基于人群的环境中具有肝脏脂肪含量（LFC）和血清肝酶。我们使用了2700名参与者(51.7%的女性)的数据，21-90岁,来自波美拉尼亚基于人群的健康研究的两个独立队列（SHIP-START-2和SHIP-TREND-0）。横截面,使用多变量调整回归模型来检查HGS与LFC的相关性，通过磁共振成像和血清肝酶测量。我们发现HGS与LFC和血清肝酶的显着负相关。具体来说,较低的10公斤HGS与较高的0.59％（95％置信区间[CI]：0.24-0.94；p=0.001）LFC相关，0.051µkatal/L(95%CI:0.005-0.097;p=0.031)较高的γ-谷氨酰转移酶(GGT)浓度和0.010µkatal/L(95%CI:0.001-0.020;p=0.023)较高的天冬氨酸氨基转移酶(AST)浓度。每10kg较低HGS的普遍肝性脂肪变性（由MRI-PDFF≥5.1％定义）的调整后比值比为1.21（95％CI：1.04-1.40；p=0.014）。当只考虑肥胖个体时，与高HGS患者相比,低HGS患者平均LFC较高1.58%(95%CI:0.18~2.98;p=0.027),且发生普遍肝脂肪变性的机率较高(校正OR1.74,95%CI:1.15~2.62;p=0.009).我们在超重的个体中发现了类似的关联，但不是那些体重正常的人。较低的HGS与较高的LFC和较高的血清GGT和AST浓度密切相关。未来的研究可能会澄清这些发现是否反映了久坐的生活方式或衰老对肝脏的不利影响。
