PDF(Pubmed)
Abstract：
UNASSIGNED: To explore differences in the relationship between gestational age (GA) and birth weight (BW) percentile and ocular geometry between males and females.
UNASSIGNED: The Gutenberg Prematurity Eye Study involved a prospective ophthalmic examination of adults, aged 18 to 52 years, who were born preterm or at term, in Germany. The associations between GA and BW percentile on the main outcome measures were evaluated by uni- and multivariable linear regression analyses. The main outcome measures were central corneal thickness, corneal radius, anterior chamber depth, lens thickness, posterior segment length, and central foveal thickness. Potential sex-specific differences and an effect modification by sex were analyzed.
UNASSIGNED: This study involved 438 participants (245 females, 193 males) with an average age of 28.6 ± 8.7 years. In female participants, central foveal thickness was negatively associated with a higher GA (B = -2.99; P < 0.001). Similarly, male participants also demonstrated a negative association between central foveal thickness and GA (B = -4.27; P < 0.001). The multivariable model with effect modification revealed that the central foveal thickness was thicker with lower GA. There was an association between the effect modification of GA with sex and central foveal thickness, demonstrating a more pronounced effect of GA on central foveal thickness in male participants (B = 1.29; P = 0.04).
UNASSIGNED: This study identified a sex-specific correlation between lower GA and thicker central foveal thickness, suggesting differences in the developmental trajectory of this biometric parameter concerning GA. A thicker central foveal thickness might affect the visual acuity of individuals born preterm in adulthood, with a more pronounced impact in males and a potential predisposition to age-related diseases later in life. Sex did not influence the association of GA or BW percentile to other ocular geometric parameters.
UNASSIGNED: The Gutenberg Prematurity Eye Study involved a prospective ophthalmic examination of adults, aged 18 to 52 years, who were born preterm or at term, in Germany. The associations between GA and BW percentile on the main outcome measures were evaluated by uni- and multivariable linear regression analyses. The main outcome measures were central corneal thickness, corneal radius, anterior chamber depth, lens thickness, posterior segment length, and central foveal thickness. Potential sex-specific differences and an effect modification by sex were analyzed.
UNASSIGNED: This study involved 438 participants (245 females, 193 males) with an average age of 28.6 ± 8.7 years. In female participants, central foveal thickness was negatively associated with a higher GA (B = -2.99; P < 0.001). Similarly, male participants also demonstrated a negative association between central foveal thickness and GA (B = -4.27; P < 0.001). The multivariable model with effect modification revealed that the central foveal thickness was thicker with lower GA. There was an association between the effect modification of GA with sex and central foveal thickness, demonstrating a more pronounced effect of GA on central foveal thickness in male participants (B = 1.29; P = 0.04).
UNASSIGNED: This study identified a sex-specific correlation between lower GA and thicker central foveal thickness, suggesting differences in the developmental trajectory of this biometric parameter concerning GA. A thicker central foveal thickness might affect the visual acuity of individuals born preterm in adulthood, with a more pronounced impact in males and a potential predisposition to age-related diseases later in life. Sex did not influence the association of GA or BW percentile to other ocular geometric parameters.
摘要：
■探讨男性和女性之间胎龄（GA）与出生体重（BW）百分位数和眼部几何形状之间关系的差异。
■古腾堡早产儿眼科研究涉及对成年人进行前瞻性眼科检查，18至52岁，谁是早产或足月出生，在德国。通过单变量和多变量线性回归分析评估主要结局指标的GA和BW百分位数之间的关联。主要结果测量为中央角膜厚度，角膜半径,前房深度,透镜厚度,后段长度，中央凹厚度。分析了潜在的性别特异性差异和按性别进行的效应修饰。
■这项研究涉及438名参与者（245名女性，193名男性），平均年龄28.6±8.7岁。在女性参与者中，中央凹厚度与较高的GA呈负相关(B=-2.99;P<0.001)。同样，男性参与者还显示中央凹厚度与GA之间呈负相关(B=-4.27;P<0.001).具有效应修正的多变量模型表明，中心凹厚度随着GA的降低而较厚。GA的效果改变与性别和中央凹厚度之间存在关联，证明GA对男性参与者中央凹厚度的影响更明显（B=1.29；P=0.04）。
■这项研究确定了较低的GA和较厚的中央中央凹厚度之间的性别特异性相关性，表明该生物特征参数与GA有关的发展轨迹存在差异。中央凹厚度较厚可能会影响成年期早产儿的视力，对男性的影响更为明显，并且在以后的生活中可能容易患上与年龄有关的疾病。性别不影响GA或BW百分位数与其他眼部几何参数的关联。
■古腾堡早产儿眼科研究涉及对成年人进行前瞻性眼科检查，18至52岁，谁是早产或足月出生，在德国。通过单变量和多变量线性回归分析评估主要结局指标的GA和BW百分位数之间的关联。主要结果测量为中央角膜厚度，角膜半径,前房深度,透镜厚度,后段长度，中央凹厚度。分析了潜在的性别特异性差异和按性别进行的效应修饰。
■这项研究涉及438名参与者（245名女性，193名男性），平均年龄28.6±8.7岁。在女性参与者中，中央凹厚度与较高的GA呈负相关(B=-2.99;P<0.001)。同样，男性参与者还显示中央凹厚度与GA之间呈负相关(B=-4.27;P<0.001).具有效应修正的多变量模型表明，中心凹厚度随着GA的降低而较厚。GA的效果改变与性别和中央凹厚度之间存在关联，证明GA对男性参与者中央凹厚度的影响更明显（B=1.29；P=0.04）。
■这项研究确定了较低的GA和较厚的中央中央凹厚度之间的性别特异性相关性，表明该生物特征参数与GA有关的发展轨迹存在差异。中央凹厚度较厚可能会影响成年期早产儿的视力，对男性的影响更为明显，并且在以后的生活中可能容易患上与年龄有关的疾病。性别不影响GA或BW百分位数与其他眼部几何参数的关联。
