METHODS: Twenty-two patients with cortical myoclonus having giant SEPs (patient group) and 15 healthy controls were included in this study. Waveform changes in SEPs before and after perampanel (PER) treatment were evaluated in the patient group. The wide range, time-frequency properties underlying the waveforms were compared between the groups.
RESULTS: After PER treatment, SLC was prolonged and positively correlated with PER concentration, whereas MLC showed no correlation with PER concentration. Time-frequency analysis showed a power increase (156 Hz in all patients, 624 Hz in benign adult familial myoclonus epilepsy patients) underlying SLC and a power decrease (156 Hz, 624 Hz) underlying MLC in the patient group.
CONCLUSIONS: The high-frequency power increase in SLCs and decrease in MLCs clearly reflected PDS and subsequent hyperpolarization, respectively. This relationship was similar to that of interictal epileptiform discharges, suggesting that giant SEPs evoke epileptic complexes of excitatory and inhibitory components.
CONCLUSIONS: MLCs of giant SEPs reflected inhibitory components.
方法:本研究包括22例具有巨大SEP的皮质肌阵挛症患者(患者组)和15例健康对照。在患者组中评估了PER治疗前后SEP的波形变化。范围广,组间比较了波形的时频特性.
结果:PER治疗后,SLC时间延长,与PER浓度呈正相关,而MLC与PER浓度无相关性。时频分析显示功率增加(所有患者为156Hz,在良性成人家族性肌阵挛性癫痫患者中,624Hz)的SLC和功率下降(156Hz,624Hz)患者组中的潜在MLC。
结论:SLC的高频功率增加和MLC的减少清楚地反映了PDS和随后的超极化,分别。这种关系类似于发作间癫痫样放电,这表明巨大的SEP会引起兴奋性和抑制性成分的癫痫复合物。
结论:巨大SEP的MLC反映了抑制成分。