Abstract：
BACKGROUND: Multisystem inflammatory syndrome in children (MIS-C) is a serious hyperinflammatory condition associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Usually, the diagnosis of MIS-C is made by criteria defined by international organizations, which include specific clinical features, laboratory findings, and evidence of SARS-CoV-2 infection. We hereby present a case series of three children. The objective of this case series, involving chart review of medical records of children admitted with MIS-C, is to emphasize that the features of MIS-C may overlap with other conditions.
METHODS: Three children were presented with MIS-C based on World Health Organization (WHO) criteria and given treatment for the same. However, due to persistent symptoms, they were further worked up and diagnosed to have underlying bacterial infections which included liver abscess, enteric fever, or urinary tract infection.
CONCLUSIONS: The criteria for MIS-C may overlap with other conditions, particularly bacterial infection that may lead to overdiagnosis of MIS-C. Therefore, one should be very careful in making an MIS-C diagnosis and other differential diagnoses should be considered when the symptoms persist or worsen.
METHODS: Three children were presented with MIS-C based on World Health Organization (WHO) criteria and given treatment for the same. However, due to persistent symptoms, they were further worked up and diagnosed to have underlying bacterial infections which included liver abscess, enteric fever, or urinary tract infection.
CONCLUSIONS: The criteria for MIS-C may overlap with other conditions, particularly bacterial infection that may lead to overdiagnosis of MIS-C. Therefore, one should be very careful in making an MIS-C diagnosis and other differential diagnoses should be considered when the symptoms persist or worsen.
摘要：
背景：儿童多系统炎症综合征（MIS-C）是与严重急性呼吸道综合征冠状病毒-2（SARS-CoV-2）感染相关的严重高炎性病症。通常,MIS-C的诊断是根据国际组织定义的标准进行的，其中包括特定的临床特征，实验室发现,和SARS-CoV-2感染的证据。我们在此介绍一系列三个孩子的案例。这个案例系列的目的，包括对接受MIS-C的儿童的医疗记录进行图表审查，是为了强调MIS-C的特征可能与其他条件重叠。
方法：根据世界卫生组织（WHO）标准，对3名儿童进行了MIS-C检查，并给予相同的治疗。然而,由于持续的症状，他们被进一步研究和诊断有潜在的细菌感染，包括肝脓肿，肠热,或者尿路感染.
结论：MIS-C的标准可能与其他条件重叠，特别是可能导致MIS-C过度诊断的细菌感染。因此,在进行MIS-C诊断时应非常小心,当症状持续或恶化时,应考虑其他鉴别诊断.
方法：根据世界卫生组织（WHO）标准，对3名儿童进行了MIS-C检查，并给予相同的治疗。然而,由于持续的症状，他们被进一步研究和诊断有潜在的细菌感染，包括肝脓肿，肠热,或者尿路感染.
结论：MIS-C的标准可能与其他条件重叠，特别是可能导致MIS-C过度诊断的细菌感染。因此,在进行MIS-C诊断时应非常小心,当症状持续或恶化时,应考虑其他鉴别诊断.
