PDF(Pubmed)
Abstract：
Candida auris is an evolving and concerning global threat. Of particular concern are bloodstream infections related to central venous catheters. We evaluated the activity of taurolidine, a broad-spectrum antimicrobial in catheter lock solutions, against 106 C. auris isolates. Taurolidine was highly active with a MIC50/MIC90 of 512/512 mg/L, over 20-fold lower than lock solution concentrations of ≥13,500 mg/L. Our data demonstrate a theoretical basis for taurolidine-based lock solutions for prevention of C. auris catheter-associated infections.
摘要：
念珠菌是一种不断发展的全球性威胁。特别关注的是与中心静脉导管相关的血流感染。我们评估了牛磺罗定的活性，导管锁定溶液中的广谱抗微生物剂，针对106个大肠杆菌分离株。牛磺罗定具有高度活性，MIC50/MIC90为512/512mg/L，比浓度≥13,500mg/L的锁定溶液低20倍以上我们的数据证明了基于牛磺罗定的锁定溶液用于预防耳梭菌导管相关感染的理论基础。
