{Reference Type}: Journal Article
{Title}: In vitro activity of taurolidine against clinical Candida auris isolates: relevance to catheter-related bloodstream infections.
{Author}: Reidenberg BE;Jenkins SG;Crandon JL;Hurlburt E;Tan X;Rhomberg PR;Arends SJR;Pfaffle A;
{Journal}: Antimicrob Agents Chemother
{Volume}: 68
{Issue}: 7
{Year}: 2024 Jul 9
{Factor}: 5.938
{DOI}: 10.1128/aac.00381-24
{Abstract}: Candida auris is an evolving and concerning global threat. Of particular concern are bloodstream infections related to central venous catheters. We evaluated the activity of taurolidine, a broad-spectrum antimicrobial in catheter lock solutions, against 106 C. auris isolates. Taurolidine was highly active with a MIC50/MIC90 of 512/512 mg/L, over 20-fold lower than lock solution concentrations of ≥13,500 mg/L. Our data demonstrate a theoretical basis for taurolidine-based lock solutions for prevention of C. auris catheter-associated infections.