%0 Journal Article
%T In vitro activity of taurolidine against clinical Candida auris isolates: relevance to catheter-related bloodstream infections.
%A Reidenberg BE
%A Jenkins SG
%A Crandon JL
%A Hurlburt E
%A Tan X
%A Rhomberg PR
%A Arends SJR
%A Pfaffle A
%J Antimicrob Agents Chemother
%V 68
%N 7
%D 2024 Jul 9
%M 38864612
%F 5.938
%R 10.1128/aac.00381-24
%X Candida auris is an evolving and concerning global threat. Of particular concern are bloodstream infections related to central venous catheters. We evaluated the activity of taurolidine, a broad-spectrum antimicrobial in catheter lock solutions, against 106 C. auris isolates. Taurolidine was highly active with a MIC50/MIC90 of 512/512 mg/L, over 20-fold lower than lock solution concentrations of ≥13,500 mg/L. Our data demonstrate a theoretical basis for taurolidine-based lock solutions for prevention of C. auris catheter-associated infections.