在 D - GalN / LPS 诱导的肝脓毒症中发现 7 - 烷氧基苯并呋喃作为具有肝保护活性的 PDE4 抑制剂。
关键词: 7-Methoxybenzofurans D-GalN/LPS-Induced liver injury Oral bioavailability PDE4 inhibitors
Mesh : Animals Humans Male Rats Benzofurans / pharmacology chemistry chemical synthesis Chemical and Drug Induced Liver Injury / drug therapy Cyclic Nucleotide Phosphodiesterases, Type 4 / metabolism Dose-Response Relationship, Drug Drug Discovery Galactosamine / pharmacology Lipopolysaccharides / pharmacology antagonists & inhibitors Liver / drug effects pathology Molecular Docking Simulation Molecular Structure Phosphodiesterase 4 Inhibitors / pharmacology chemistry chemical synthesis Protective Agents / pharmacology chemistry chemical synthesis Rats, Sprague-Dawley Sepsis / drug therapy Structure-Activity Relationship
来 源: DOI:10.1016/j.ejmech.2024.116576