PDF(Pubmed)
Abstract：
UNASSIGNED: Helicobacter pylori infection is a common gastrointestinal infection that affects around 50% of the global population. This infection can lead to various health conditions such as peptic ulcer disease, dyspepsia, gastric carcinoma, and mucosa-associated lymphoid tissue lymphoma. The triple therapy which consists of proton-pump inhibitors, clarithromycin, and amoxicillin or metronidazole for 14 days is considered the first-line treatment for H. pylori and its eradication, especially in areas where clarithromycin sensitivity is still high. However, recent research shows that the efficacy of this treatment is decreasing due to antibiotic resistance.
UNASSIGNED: This was a retrospective study that took place at Al-Hayat Jazan Hospital in Jazan, Saudi Arabia. The study analyzed the medical records of 186 patients with H. pylori who had undergone the standard triple therapy. The objectives of this study were to determine the eradication rate of H. pylori by using the standard triple therapy, and to highlight the influence of some demographic characteristics such as age, gender, diabetes mellitus, and smoking on the eradication rate, in Jazan region, Saudi Arabia.
UNASSIGNED: The medical records of 186 patients were included in the study. The overall rate of successful eradication was found to be 77.4%. The results of the study showed that the decline in the eradication rate was significantly associated with the presence of diabetes and smoking status (with p-values of <0.001 and <0.004, respectively).
UNASSIGNED: This study finds that the standard triple therapy for H. pylori eradication is less effective than optimal standards, as per literature and guidelines. Given its declining efficacy globally, alternative first-line treatments may be necessary. Further research is needed to assess its effectiveness in various regional contexts.
UNASSIGNED: This was a retrospective study that took place at Al-Hayat Jazan Hospital in Jazan, Saudi Arabia. The study analyzed the medical records of 186 patients with H. pylori who had undergone the standard triple therapy. The objectives of this study were to determine the eradication rate of H. pylori by using the standard triple therapy, and to highlight the influence of some demographic characteristics such as age, gender, diabetes mellitus, and smoking on the eradication rate, in Jazan region, Saudi Arabia.
UNASSIGNED: The medical records of 186 patients were included in the study. The overall rate of successful eradication was found to be 77.4%. The results of the study showed that the decline in the eradication rate was significantly associated with the presence of diabetes and smoking status (with p-values of <0.001 and <0.004, respectively).
UNASSIGNED: This study finds that the standard triple therapy for H. pylori eradication is less effective than optimal standards, as per literature and guidelines. Given its declining efficacy globally, alternative first-line treatments may be necessary. Further research is needed to assess its effectiveness in various regional contexts.
摘要：
幽门螺杆菌感染是一种常见的胃肠道感染，影响全球约50％的人口。这种感染会导致各种健康状况，如消化性溃疡疾病，消化不良,胃癌,和粘膜相关淋巴组织淋巴瘤。由质子泵抑制剂组成的三联疗法，克拉霉素,和阿莫西林或甲硝唑14天被认为是幽门螺杆菌的一线治疗和根除，特别是在克拉霉素敏感性仍然很高的地区。然而,最近的研究表明，由于抗生素耐药性，这种治疗的疗效正在下降。
这是一项在Jazan的Al-HayatJazan医院进行的回顾性研究，沙特阿拉伯。该研究分析了186例接受标准三联疗法的幽门螺杆菌患者的医疗记录。本研究的目的是通过使用标准三联疗法来确定幽门螺杆菌的根除率。并强调一些人口特征的影响，如年龄，性别,糖尿病,和吸烟对根除率的影响，在Jazan地区,沙特阿拉伯。
■研究中纳入了186名患者的医疗记录。根除成功率为77.4%。研究结果表明，根除率的下降与糖尿病和吸烟状况的存在显着相关（p值分别为<0.001和<0.004）。
■这项研究发现，根除幽门螺杆菌的标准三联疗法不如最佳标准有效，根据文献和指南。鉴于其在全球范围内的疗效下降，替代一线治疗可能是必要的。需要进一步研究以评估其在各种区域背景下的有效性。
这是一项在Jazan的Al-HayatJazan医院进行的回顾性研究，沙特阿拉伯。该研究分析了186例接受标准三联疗法的幽门螺杆菌患者的医疗记录。本研究的目的是通过使用标准三联疗法来确定幽门螺杆菌的根除率。并强调一些人口特征的影响，如年龄，性别,糖尿病,和吸烟对根除率的影响，在Jazan地区,沙特阿拉伯。
■研究中纳入了186名患者的医疗记录。根除成功率为77.4%。研究结果表明，根除率的下降与糖尿病和吸烟状况的存在显着相关（p值分别为<0.001和<0.004）。
■这项研究发现，根除幽门螺杆菌的标准三联疗法不如最佳标准有效，根据文献和指南。鉴于其在全球范围内的疗效下降，替代一线治疗可能是必要的。需要进一步研究以评估其在各种区域背景下的有效性。
