PDF(Pubmed)
Abstract：
UNASSIGNED: Muscle mass gradually declines with advancing age, and as an anti-aging protein, klotho may be associated with muscle mass. This study aims to explore the relationship between klotho levels and muscle mass in the middle-aged population.
UNASSIGNED: Utilizing data from the National Health and Nutrition Examination Survey (NHANES) spanning 2011 to 2018, we conducted a cross-sectional analysis on a cohort of individuals aged 40-59. Weighted multivariable analysis was employed to assess the correlation between klotho and low muscle mass, with stratified and Restricted Cubic Spline (RCS) analyses.
UNASSIGNED: The cross-sectional investigation revealed a significant negative correlation between klotho levels and the risk of low muscle mass (Model 3: OR = 0.807, 95% CI: 0.712-0.915). A notable interaction between klotho and sex was observed, with a significant interaction effect (P for interaction = 0.01). The risk association was notably higher in females. The risk association was notably higher in females. Additionally, RCS analysis unveiled a significant linear relationship between klotho and low muscle mass (P for nonlinear = 0.9495, P for overall<0.0001).
UNASSIGNED: Our observational analysis revealed a noteworthy inverse relationship between klotho and low muscle mass, particularly prominent among female participants. This discovery provides crucial insights for the development of more effective intervention strategies and offers a new direction for enhancing muscle quality in the middle-aged population.
UNASSIGNED: Utilizing data from the National Health and Nutrition Examination Survey (NHANES) spanning 2011 to 2018, we conducted a cross-sectional analysis on a cohort of individuals aged 40-59. Weighted multivariable analysis was employed to assess the correlation between klotho and low muscle mass, with stratified and Restricted Cubic Spline (RCS) analyses.
UNASSIGNED: The cross-sectional investigation revealed a significant negative correlation between klotho levels and the risk of low muscle mass (Model 3: OR = 0.807, 95% CI: 0.712-0.915). A notable interaction between klotho and sex was observed, with a significant interaction effect (P for interaction = 0.01). The risk association was notably higher in females. The risk association was notably higher in females. Additionally, RCS analysis unveiled a significant linear relationship between klotho and low muscle mass (P for nonlinear = 0.9495, P for overall<0.0001).
UNASSIGNED: Our observational analysis revealed a noteworthy inverse relationship between klotho and low muscle mass, particularly prominent among female participants. This discovery provides crucial insights for the development of more effective intervention strategies and offers a new direction for enhancing muscle quality in the middle-aged population.
摘要：
■肌肉质量随着年龄的增长而逐渐下降，作为一种抗衰老蛋白质，klotho可能与肌肉质量有关。本研究旨在探讨中年人群klotho水平与肌肉质量之间的关系。
■利用2011年至2018年国家健康和营养调查（NHANES）的数据，我们对40-59岁的人群进行了横断面分析。加权多变量分析用于评估klotho和低肌肉质量之间的相关性，采用分层和受限三次样条(RCS)分析。
■横断面调查显示，klotho水平与低肌肉质量风险之间存在显着负相关（模型3：OR=0.807，95％CI：0.712-0.915）。观察到klotho和性别之间的显着相互作用，具有显著的交互作用(交互作用P=0.01)。女性的风险关联明显更高。女性的风险关联明显更高。此外,RCS分析揭示了klotho和低肌肉质量之间的显着线性关系（非线性P=0.9495，总体P<0.0001）。
■我们的观察分析显示，klotho和低肌肉质量之间存在显著的反比关系，在女性参与者中尤为突出。这一发现为制定更有效的干预策略提供了重要的见解，并为提高中年人群的肌肉质量提供了新的方向。
■利用2011年至2018年国家健康和营养调查（NHANES）的数据，我们对40-59岁的人群进行了横断面分析。加权多变量分析用于评估klotho和低肌肉质量之间的相关性，采用分层和受限三次样条(RCS)分析。
■横断面调查显示，klotho水平与低肌肉质量风险之间存在显着负相关（模型3：OR=0.807，95％CI：0.712-0.915）。观察到klotho和性别之间的显着相互作用，具有显著的交互作用(交互作用P=0.01)。女性的风险关联明显更高。女性的风险关联明显更高。此外,RCS分析揭示了klotho和低肌肉质量之间的显着线性关系（非线性P=0.9495，总体P<0.0001）。
■我们的观察分析显示，klotho和低肌肉质量之间存在显著的反比关系，在女性参与者中尤为突出。这一发现为制定更有效的干预策略提供了重要的见解，并为提高中年人群的肌肉质量提供了新的方向。
