Abstract：
Synaptic plasticity is a key cellular model for learning, memory and chronic pain. Most previous studies were carried out in rats and mice, and less is known about synaptic plasticity in non-human primates. In the present study, we used integrative experimental approaches to study long-term potentiation (LTP) in the anterior cingulate cortex (ACC) of adult tree shrews. We found that glutamate is the major excitatory transmitter and α-amino-3-hydroxy-5-methyl-4-isoxazole-propionicacid (AMPA) receptors mediate postsynaptic responses. LTP in tree shrews was greater than that in adult mice and lasted for at least 5 h. N-methyl-d-aspartic acid (NMDA) receptors, Ca2+ influx and adenylyl cyclase 1 (AC1) contributed to tree shrew LTP. Our results suggest that LTP is a major form of synaptic plasticity in the ACC of primate-like animals. This article is part of a discussion meeting issue \'Long-term potentiation: 50 years on\'.
摘要：
突触可塑性是学习的关键细胞模型，记忆和慢性疼痛。以前的大多数研究都是在大鼠和小鼠中进行的，对非人灵长类动物的突触可塑性知之甚少。在本研究中,我们使用综合实验方法研究了成年树sh的前扣带回皮质（ACC）的长期增强（LTP）。我们发现谷氨酸是主要的兴奋性递质，α-氨基-3-羟基-5-甲基-4-异恶唑-丙酸（AMPA）受体介导突触后反应。树sh的LTP大于成年小鼠，持续至少5小时。N-甲基-d-天冬氨酸（NMDA）受体，Ca2内流和腺苷酸环化酶1（AC1）有助于树theLTP。我们的结果表明，LTP是灵长类动物ACC中突触可塑性的主要形式。本文是讨论会议问题“长期增强：50年后”的一部分。
