%0 Journal Article
%T Enhanced long-term potentiation in the anterior cingulate cortex of tree shrew.
%A Song Q
%A Li XH
%A Lu JS
%A Chen QY
%A Liu RH
%A Zhou SB
%A Zhuo M
%J Philos Trans R Soc Lond B Biol Sci
%V 379
%N 1906
%D 2024 Jul 29
%M 38853555
%F 6.671
%R 10.1098/rstb.2023.0240
%X Synaptic plasticity is a key cellular model for learning, memory and chronic pain. Most previous studies were carried out in rats and mice, and less is known about synaptic plasticity in non-human primates. In the present study, we used integrative experimental approaches to study long-term potentiation (LTP) in the anterior cingulate cortex (ACC) of adult tree shrews. We found that glutamate is the major excitatory transmitter and α-amino-3-hydroxy-5-methyl-4-isoxazole-propionicacid (AMPA) receptors mediate postsynaptic responses. LTP in tree shrews was greater than that in adult mice and lasted for at least 5 h. N-methyl-d-aspartic acid (NMDA) receptors, Ca2+ influx and adenylyl cyclase 1 (AC1) contributed to tree shrew LTP. Our results suggest that LTP is a major form of synaptic plasticity in the ACC of primate-like animals. This article is part of a discussion meeting issue 'Long-term potentiation: 50 years on'.