Abstract：
Superior multifunctional hydrogel dressings are of considerable interest in wound healing. In clinical practice, it is useful to investigate hydrogel dressings that offer multifunctional benefits to expedite the process of wound healing. In this study, Catechol-grafted Chitosan, Gelatin, and Fe3+ as substrates to construct a hydrogel network. The network was dynamically cross-linked to form Ccg@Fe hydrogel substrate. Fe3O4 nanoparticles and baicalin, which possess antimicrobial and anti-inflammatory properties, were loaded onto the substrate to form a photothermal antibacterial composite hydrogel dressing (Ccg@Fe/Bai@Fe3O4 NPs). The Ccg@Fe hydrogel was characterised using Fourier transform infrared spectroscopy (FTIR) and Ultraviolet-visible spectrophotometry (UV-Vis). The morphological, mechanical, and adhesion properties of the hydrogel were determined using scanning electron microscopy (SEM) and a universal testing machine. The hydrogel\'s swelling, hemostasis, and self-healing properties were also evaluated. Additionally, the study determined the release rate of hydrogel-loaded antimicrobial and anti-inflammatory Baicalin (Ccg@Fe/Bai) and evaluated the photothermal antimicrobial properties of hydrogel-loaded Fe3O4 nanoparticles (Ccg@Fe/Bai@Fe3O4 NPs) through synergistic photothermal therapy (PTT). Histological staining of mice skin wound tissues using Masson and H&E revealed that the Ccg@Fe/Bai@Fe3O4 NPs hydrogel dressing demonstrated potential healing ability with the aid of PTT. The study suggests that this multifunctional hydrogel dressing has great potential for wound healing.
摘要：
优越的多功能水凝胶敷料在伤口愈合方面具有相当大的意义。在临床实践中,研究提供多功能益处以加快伤口愈合过程的水凝胶敷料是有用的。在这项研究中,儿茶酚接枝壳聚糖，明胶,以Fe3+为底物构建水凝胶网络。将该网络动态交联以形成Ccg@Fe水凝胶基底。Fe3O4纳米颗粒和黄芩苷，具有抗菌和抗炎特性，负载到基底上形成光热抗菌复合水凝胶敷料(Ccg@Fe/Bai@Fe3O4NPs)。使用傅里叶变换红外光谱(FTIR)和紫外-可见分光光度法(UV-Vis)表征Ccg@Fe水凝胶。形态学,机械,使用扫描电子显微镜（SEM）和万能试验机确定水凝胶的粘附性能。水凝胶的膨胀，止血,和自我修复性能也进行了评估。此外,该研究确定了水凝胶负载的抗菌和抗炎黄芩苷（Ccg@Fe/Bai）的释放速率，并通过协同光热治疗（PTT）评估了水凝胶负载的Fe3O4纳米颗粒（Ccg@Fe/Bai@Fe3O4NPs）的光热抗菌性能。使用Masson和H＆E对小鼠皮肤伤口组织进行组织学染色显示，Ccg@Fe/Bai@Fe3O4NPs水凝胶敷料在PTT的帮助下显示出潜在的愈合能力。研究表明，这种多功能水凝胶敷料具有很大的伤口愈合潜力。
