Abstract：
Vaccination has become a widely used method to induce immune protection against microbial pathogens, including viral and bacterial microorganisms. Both humoral and cellular immunity serve a critical role in neutralizing and eliminating these pathogens. An effective vaccine should be able to induce a long-lasting immune memory response. Recent investigations on different subsets of T cells have identified a new subset of T cells using multi-parameter flow cytometry, which possess stem cell-like properties and the ability to mount a rapid immune response upon re-exposure to antigens known as stem cell-like memory T cells (TSCM). One of the major challenges with current vaccines is their limited ability to maintain long-term memory in the adaptive immune system. Recent evidence suggests that a specific subgroup of memory T cells has the unique ability to retain their longevity for up to 25 years, as observed in the case of the yellow fever vaccine. Therefore, in this study, we tried to explore and discuss the potential role of this new T cell memory subset in the development of viral and bacterial vaccines.
摘要：
疫苗接种已成为一种广泛用于诱导针对微生物病原体的免疫保护的方法，包括病毒和细菌微生物。体液和细胞免疫在中和和消除这些病原体中起关键作用。有效的疫苗应该能够诱导持久的免疫记忆反应。最近对不同T细胞亚群的研究已经使用多参数流式细胞术鉴定了新的T细胞亚群。它具有干细胞样特性，并且能够在重新暴露于称为干细胞样记忆T细胞（TSCM）的抗原时产生快速的免疫反应。当前疫苗的主要挑战之一是它们在适应性免疫系统中维持长期记忆的能力有限。最近的证据表明，记忆T细胞的特定亚组具有独特的能力，可以保持长达25年的寿命，正如在黄热病疫苗的情况下观察到的那样。因此,在这项研究中，我们试图探索和讨论这种新的T细胞记忆亚群在病毒和细菌疫苗开发中的潜在作用。
