Abstract：
The widespread presence of microplastics and nanoplastics (MPs/NPs) in the environment has become a critical public health issue due to their potential to infiltrate and affect various biological systems. Our review is crucial as it consolidates current data and provides a comprehensive analysis of the cardiovascular impacts of MPs/NPs across species, highlighting significant implications for human health. By synthesizing findings from studies on aquatic and terrestrial organisms, including humans, this review offers insights into the ubiquity of MPs/NPs and their pathophysiological roles in cardiovascular systems. We demonstrated that exposure to MPs/NPs is linked to various cardiovascular ailments such as thrombogenesis, vascular damage, and cardiac impairments in model organisms, which likely extrapolate to humans. Our review critically evaluated methods for detecting MPs/NPs in biological tissues, assessing their toxicity, and understanding their behaviour within the vasculature. These findings emphasise the urgent need for targeted public health strategies and enhanced regulatory measures to mitigate the impacts of MP/NP pollution. Furthermore, the review underlined the necessity of advancing research methodologies to explore long-term effects and potential intergenerational consequences of MP/NP exposure. By mapping out the intricate links between environmental exposure and cardiovascular risks, our work served as a pivotal reference for future research and policymaking aimed at curbing the burgeoning threat of plastic pollution.
摘要：
微塑料和纳米塑料（MPs/NPs）在环境中的广泛存在已成为关键的公共卫生问题，因为它们有可能渗透并影响各种生物系统。我们的审查是至关重要的，因为它巩固了当前的数据，并提供了跨物种MPs/NPs的心血管影响的全面分析，强调对人类健康的重大影响。通过综合水生和陆生生物研究的结果，包括人类,这篇综述提供了有关MPs/NPs无处不在及其在心血管系统中的病理生理作用的见解。我们证明，暴露于MPs/NPs与各种心血管疾病有关，如血栓形成，血管损伤,和模式生物的心脏损伤，这可能会推断到人类。我们的综述严格评估了检测生物组织中MPs/NPs的方法，评估它们的毒性，了解他们在脉管系统中的行为。这些发现强调迫切需要有针对性的公共卫生战略和加强监管措施，以减轻MP/NP污染的影响。此外，该综述强调了推进研究方法以探索MP/NP暴露的长期影响和潜在的代际后果的必要性.通过绘制出环境暴露与心血管风险之间的复杂联系，我们的工作为未来旨在遏制塑料污染迅速发展的威胁的研究和政策制定提供了关键参考。
