Abstract：
Prevention and treatment protocols for taste changes observed during hematopoietic cell transplantation (HCT) are not well-established. The purpose of this study was to assess the efficacy of photobiomodulation (PBM) in relieving taste changes and preventing lingual papillae atrophy. HCT patients received PBM (n = 42) on the tongue dorsum using an InGaAIP laser (660 nm, 100 mW, 1.1 W/cm2, 8.8 J/cm2). During the HCT conditioning (T0), severe neutropenia (T1), and after neutrophil engraftment (T2), taste acuity for sweet, bitter, sour, and salty solutions, and clinical appearance of lingual papillae were compared with those of a placebo group (n = 43). PBM significantly reduced hypogeusia, ageusia, and parageusia at T1 and T2, and also successfully prevented papillae atrophy during all the analyzed HCT periods. In conclusion, PBM enhanced taste acuity during HCT. The decrease in papillae atrophy indicated a potential regenerative effect of this therapy on tongue mucosa.
摘要：
在造血细胞移植（HCT）期间观察到的味觉变化的预防和治疗方案尚未建立。这项研究的目的是评估光生物调节（PBM）在缓解味觉变化和预防舌乳头萎缩方面的功效。HCT患者使用InGaAIP激光（660nm，100mW,1.1W/cm2,8.8J/cm2)。在HCT调节期间（T0），严重中性粒细胞减少症（T1），中性粒细胞植入后（T2），味觉敏锐度为甜，苦涩,酸,和咸溶液，并将舌乳头的临床表现与安慰剂组（n=43）进行了比较。PBM显着减少了伪善，Ageusia,在T1和T2时出现假性，并且在所有分析的HCT期间都成功地预防了乳头萎缩。总之,PBM增强HCT期间的味觉敏锐度。乳头萎缩的减少表明该疗法对舌粘膜具有潜在的再生作用。
