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Abstract：
BACKGROUND: Several studies have observed that mentalization-based treatment (MBT) is an effective treatment for borderline personality disorder (BPD), but its effectiveness for other personality disorders (PDs) has hardly been examined. Additionally, the evidence supporting the claim that MBT improves mentalizing capacity is scarce. The present study examined whether (i) patients with a broad range of PDs enrolled in an MBT program would improve on several outcome measures (ii) mentalizing capacity would improve over time; (iii) patients with BPD would improve more than those with non-borderline PDs.
METHODS: Personality disorders, psychiatric symptoms, social functioning, maladaptive personality functioning and mentalizing capacity were measured in a group of individuals with various PDs (n = 46) that received MBT. Assessments were made at baseline and after 6, 12, and 18 months of treatment. The severity of psychiatric symptoms, measured using the Outcome Questionnaire 45, was the primary outcome variable.
RESULTS: Overall, enrollment in the MBT program was associated with a decrease in psychiatric symptoms and an improvement of personality functioning, social functioning for a mixed group of PDs (all p\'s ≤ .01). Bigger effect sizes were observed for BPD patients (n = 25) than for patients with non-BPD (n = 21), but the difference failed to reach statistical significance (p = 0.06). A primary analysis showed that the decrease in psychiatric symptoms was significant in BPD patients (p = 0.01), not in non-BPD (p = 0.19) patients. However, a sufficiently powered secondary analysis with imputed data showed that non-BPD patients reported a significant decrease in psychiatric symptoms too (p = 0.01). Mentalizing capacity of the whole group improved over time (d = .68 on the Toronto Alexithymia Scale and 1.46 on the Social Cognition and Object Relations System).
CONCLUSIONS: These results suggest that MBT coincides with symptomatic and functional improvement across a broad range of PDs and shows that MBT is associated with improvements in mentalizing capacity. As the study is not experimental in design, we cannot make causal claims.
CONCLUSIONS: Mentalization-based treatment may be an effective treatment for patients with a broad range of PDs.
BACKGROUND: The study design was approved by the Leiden University Ethical Committee.
METHODS: Personality disorders, psychiatric symptoms, social functioning, maladaptive personality functioning and mentalizing capacity were measured in a group of individuals with various PDs (n = 46) that received MBT. Assessments were made at baseline and after 6, 12, and 18 months of treatment. The severity of psychiatric symptoms, measured using the Outcome Questionnaire 45, was the primary outcome variable.
RESULTS: Overall, enrollment in the MBT program was associated with a decrease in psychiatric symptoms and an improvement of personality functioning, social functioning for a mixed group of PDs (all p\'s ≤ .01). Bigger effect sizes were observed for BPD patients (n = 25) than for patients with non-BPD (n = 21), but the difference failed to reach statistical significance (p = 0.06). A primary analysis showed that the decrease in psychiatric symptoms was significant in BPD patients (p = 0.01), not in non-BPD (p = 0.19) patients. However, a sufficiently powered secondary analysis with imputed data showed that non-BPD patients reported a significant decrease in psychiatric symptoms too (p = 0.01). Mentalizing capacity of the whole group improved over time (d = .68 on the Toronto Alexithymia Scale and 1.46 on the Social Cognition and Object Relations System).
CONCLUSIONS: These results suggest that MBT coincides with symptomatic and functional improvement across a broad range of PDs and shows that MBT is associated with improvements in mentalizing capacity. As the study is not experimental in design, we cannot make causal claims.
CONCLUSIONS: Mentalization-based treatment may be an effective treatment for patients with a broad range of PDs.
BACKGROUND: The study design was approved by the Leiden University Ethical Committee.
摘要：
背景：一些研究观察到，基于心理化的治疗（MBT）是边缘性人格障碍（BPD）的有效治疗方法，但其对其他人格障碍（PD）的有效性几乎没有被检查。此外,支持MBT提高思维能力的说法的证据很少。本研究检查了（i）参加MBT计划的广泛PD患者是否会改善几种结果指标（ii）随着时间的推移，心理能力会改善；（iii）BPD患者比非临界PD患者改善更多。
方法：人格障碍，精神症状,社会功能,在一组接受MBT的具有各种PD（n=46）的个体中测量了适应不良的人格功能和心理能力。在基线和治疗6、12和18个月后进行评估。精神症状的严重程度，使用结果问卷45测量，是主要结果变量。
结果：总体而言，MBT项目的注册与精神症状的减少和人格功能的改善有关，PDs混合组的社会功能(所有p≤0.01)。BPD患者（n=25）比非BPD患者（n=21）观察到更大的效应大小，但差异未能达到统计学意义(p=0.06)。初步分析显示，BPD患者的精神症状明显减少（p=0.01），非BPD患者（p=0.19）。然而,对估算数据进行的足够有效的二次分析显示,非BPD患者的精神症状也显著减轻(p=0.01).整个小组的心理能力随着时间的推移而提高（多伦多述情障碍量表的d=.68，社会认知和对象关系系统的d=1.46）。
结论：这些结果表明，在广泛的PD中，MBT与症状和功能改善相一致，并表明MBT与心理能力的改善有关。由于这项研究不是实验设计，我们不能提出因果关系。
结论：对于广泛的PD患者，基于心理疗法可能是一种有效的治疗方法。
背景：研究设计得到莱顿大学伦理委员会的批准。
方法：人格障碍，精神症状,社会功能,在一组接受MBT的具有各种PD（n=46）的个体中测量了适应不良的人格功能和心理能力。在基线和治疗6、12和18个月后进行评估。精神症状的严重程度，使用结果问卷45测量，是主要结果变量。
结果：总体而言，MBT项目的注册与精神症状的减少和人格功能的改善有关，PDs混合组的社会功能(所有p≤0.01)。BPD患者（n=25）比非BPD患者（n=21）观察到更大的效应大小，但差异未能达到统计学意义(p=0.06)。初步分析显示，BPD患者的精神症状明显减少（p=0.01），非BPD患者（p=0.19）。然而,对估算数据进行的足够有效的二次分析显示,非BPD患者的精神症状也显著减轻(p=0.01).整个小组的心理能力随着时间的推移而提高（多伦多述情障碍量表的d=.68，社会认知和对象关系系统的d=1.46）。
结论：这些结果表明，在广泛的PD中，MBT与症状和功能改善相一致，并表明MBT与心理能力的改善有关。由于这项研究不是实验设计，我们不能提出因果关系。
结论：对于广泛的PD患者，基于心理疗法可能是一种有效的治疗方法。
背景：研究设计得到莱顿大学伦理委员会的批准。
