目标:我们的目标是研究心理化之间的相互作用,大脑微观结构,和心理弹性作为对抗精神疾病的潜在保护因素。
方法:四百二十六名参与者(平均年龄40.12±16.95;202名男性,224名女性),没有精神病或神经学史,已完成的评估:分离过程量表(DPS),安心(PoM)贝克抑郁量表(BDI),贝克焦虑量表(BAI),成人复原力量表(RSA),和具有选定感兴趣区域的磁共振成像(MRI)结构,和扩散张量成像(DTI)从右半球和连接到额叶区域的各种束映射,包括前丘脑辐射(ATR),扣带(海马)(CH),皮质脊髓束(CST),上纵束(SLF),下额枕骨束(IFOF),和Uncinatefasculus(UF)进行了分析。
结果:两个集群,表示超定位(HypoM)和超定位(HyperM),是根据DPS识别的,CPSS,和RFQ响应。单因素方差分析显示集群之间没有显著的年龄或性别差异。HypoM组的PoM得分较低,更高的BDI和BAI分数,和较低的RSA评分(ps<0.05)。脑结构度量比较显示右尾中额回(rcMFG)GMV有显著差异,右侧额上回(rsFG)和右侧额叶极(rFP)组间比较。此外,在rcMFG上发现具有较高的抑郁风险和较高的内部与人际关系因素的比率的HyperM个体具有降低的GMV。此外,DTI指标分析显示,两组rATR和rSLF在各向异性分数(FA)值方面存在显著差异;rATR,rCST,rUF,rSLF,以平均扩散率(MD)值表示的rCH和rIFF;以及rATR,rCH,rCST,和径向扩散系数(RD)(校正后p=0.05)。此外,韧性的不同领域与白质(WM)完整性之间的正相关表明,对于具有不同心理的人来说,个体内或人际韧性因子的进一步增强是不同的。
结论:研究结果强调了在理解与脑机制相关的心理弹性和心理健康状况之间的相互作用时,考虑内部和人际因素的重要性。
OBJECTIVE: We aim to investigate the interplay between
mentalization, brain microstructure, and psychological resilience as potential protective factors against mental illness.
METHODS: Four hundred and twenty-six participants (mean age 40.12±16.95; 202 males, 224 females), without psychiatric or neurological history, completed assessments: Dissociative Process Scale (DPS), Peace of Mind (PoM), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Resilience Scale for Adults (RSA), and Magnetic Resonance Imaging (MRI) structures with selected regions of interest, and Diffusion Tensor Imaging (DTI) maps from various tracts in the right hemisphere and connection to the frontal areas, including anterior thalamic radiation (ATR), Cingulum (hippocampus) (CH), Corticospinal tract (CST), Superior longitudinal fasciculus (SLF), Inferior fronto-occipital fasciculus (IFOF), and Uncinate fasciculus (UF) were analyzed.
RESULTS: Two clusters, representing hypomentalization (HypoM) and hypermentalization (HyperM), were identified based on DPS, CPSS, and RFQ responses. One-way ANOVA showed no significant age or gender differences between clusters. The HypoM group exhibited lower PoM scores, higher BDI and BAI scores, and lower RSA scores (ps< 0.05). Structural brain metric comparison showed significant differences in GMV in the right caudal middle frontal gyrus (rcMFG), right superior frontal gyrus (rsFG), and right frontal pole (rFP) between groups. In addition, the HyperM individuals with a higher risk of depression and a higher ratio of intrapersonal to interpersonal factors of resilience were found with reduced GMV on the rcMFG. Additionally, analyses of DTI metrics revealed significant differences between two groups in rATR and rSLF in terms of fractional anisotropy (FA) values; rATR, rCST, rUF, rSLF, rCH and rIFOF in terms of mean diffusivity (MD) values, and radial diffusivity (RD) (corrected p = 0.05). Moreover, the positive correlation between different domains of resilience and white matter (WM) integrity implied further enhancement of intrapersonal or interpersonal resilience factors that are different for people with different
mentalization.
CONCLUSIONS: The findings underscore the importance of considering both intrapersonal and interpersonal factors in understanding the interactions between psychological resilience and mental health conditions relevant to brain mechanisms.