PDF(Pubmed)
Abstract：
UNASSIGNED: Esophageal gastrointestinal stromal tumors (E-GISTs) are highly uncommon and have not been thoroughly examined.
UNASSIGNED: The objective of this multi-center study was to assess the viability of endoscopic resection (ER) in the treatment of E-GISTs and to explore its clinical implications.
UNASSIGNED: This was a multi-center retrospective study. Consecutive patients referred to the four participating centers.
UNASSIGNED: E-GISTs among the consecutive subepithelial tumors (SETs) treated by ER methods were enrolled from April 2019 to August 2022. Clinicopathological, endoscopic, and follow-up data were collected and analyzed.
UNASSIGNED: A total of 23 patients with E-GISTs were included for analysis, accounting for 1.9% of all the esophageal SETs (1243 patients). The average size of the tumor lesions was 2.3 cm (range 1.0-4.0 cm). We observed that tumors larger than 2.0 cm were more likely to grow deeper, with a statistically significant difference (p < 0.001). End bloc resection was achieved in all 23 patients. The mean operation time was 53.6 min (range 25-111 min). One patient experienced significant intraoperative bleeding, which was promptly managed endoscopically without necessitating surgery. The average hospital stay was 4.5 days (range 3-8 days). The overall median follow-up period was 31 months (range 13-47 months). No tumor recurrence, residual tumor, distal metastasis, or death was observed during the follow-up period.
UNASSIGNED: Based on our limited data, our study indicates that ER may be a feasible and effective option for treating esophageal GISTs measuring 4 cm or less. We suggest submucosal tunnel endoscopic resection as the preferred approach, as all E-GISTs in our study were situated in the muscularis propria layer. Additionally, tumors larger than 2 cm were more prone to deeper growth or extraluminal extension.
UNASSIGNED: The objective of this multi-center study was to assess the viability of endoscopic resection (ER) in the treatment of E-GISTs and to explore its clinical implications.
UNASSIGNED: This was a multi-center retrospective study. Consecutive patients referred to the four participating centers.
UNASSIGNED: E-GISTs among the consecutive subepithelial tumors (SETs) treated by ER methods were enrolled from April 2019 to August 2022. Clinicopathological, endoscopic, and follow-up data were collected and analyzed.
UNASSIGNED: A total of 23 patients with E-GISTs were included for analysis, accounting for 1.9% of all the esophageal SETs (1243 patients). The average size of the tumor lesions was 2.3 cm (range 1.0-4.0 cm). We observed that tumors larger than 2.0 cm were more likely to grow deeper, with a statistically significant difference (p < 0.001). End bloc resection was achieved in all 23 patients. The mean operation time was 53.6 min (range 25-111 min). One patient experienced significant intraoperative bleeding, which was promptly managed endoscopically without necessitating surgery. The average hospital stay was 4.5 days (range 3-8 days). The overall median follow-up period was 31 months (range 13-47 months). No tumor recurrence, residual tumor, distal metastasis, or death was observed during the follow-up period.
UNASSIGNED: Based on our limited data, our study indicates that ER may be a feasible and effective option for treating esophageal GISTs measuring 4 cm or less. We suggest submucosal tunnel endoscopic resection as the preferred approach, as all E-GISTs in our study were situated in the muscularis propria layer. Additionally, tumors larger than 2 cm were more prone to deeper growth or extraluminal extension.
摘要：
■食管胃肠道间质瘤（E-GIST）非常罕见，尚未彻底检查。
■这项多中心研究的目的是评估内镜下切除（ER）治疗E-GIST的可行性，并探讨其临床意义。
■这是一项多中心回顾性研究。连续患者转诊至四个参与中心。
■自2019年4月至2022年8月，在通过ER方法治疗的连续上皮下肿瘤（SET）中纳入了E-GIST。临床病理,内窥镜,收集和分析随访数据。
■共纳入23例E-GIST患者进行分析，占所有食管CT的1.9%(1243例)。肿瘤病灶的平均大小为2.3cm（范围1.0-4.0cm）。我们观察到大于2.0厘米的肿瘤更有可能生长得更深，具有统计学上的显著差异(p<0.001)。所有23例患者均完成了终段切除。平均手术时间为53.6分钟（范围25-111分钟）。一名患者出现术中明显出血,及时进行内镜管理，无需手术。平均住院时间为4.5天（范围3-8天）。总体中位随访期为31个月（范围13-47个月）。无肿瘤复发,残余肿瘤，远端转移,或在随访期间观察到死亡。
■根据我们有限的数据，我们的研究表明,ER可能是治疗4cm或更小的食管GIST的可行和有效的选择.我们建议将黏膜下隧道内镜切除术作为首选方法，因为我们研究中的所有E-GIST都位于固有肌层。此外,大于2厘米的肿瘤更容易发生更深的生长或腔外延伸。
■这项多中心研究的目的是评估内镜下切除（ER）治疗E-GIST的可行性，并探讨其临床意义。
■这是一项多中心回顾性研究。连续患者转诊至四个参与中心。
■自2019年4月至2022年8月，在通过ER方法治疗的连续上皮下肿瘤（SET）中纳入了E-GIST。临床病理,内窥镜,收集和分析随访数据。
■共纳入23例E-GIST患者进行分析，占所有食管CT的1.9%(1243例)。肿瘤病灶的平均大小为2.3cm（范围1.0-4.0cm）。我们观察到大于2.0厘米的肿瘤更有可能生长得更深，具有统计学上的显著差异(p<0.001)。所有23例患者均完成了终段切除。平均手术时间为53.6分钟（范围25-111分钟）。一名患者出现术中明显出血,及时进行内镜管理，无需手术。平均住院时间为4.5天（范围3-8天）。总体中位随访期为31个月（范围13-47个月）。无肿瘤复发,残余肿瘤，远端转移,或在随访期间观察到死亡。
■根据我们有限的数据，我们的研究表明,ER可能是治疗4cm或更小的食管GIST的可行和有效的选择.我们建议将黏膜下隧道内镜切除术作为首选方法，因为我们研究中的所有E-GIST都位于固有肌层。此外,大于2厘米的肿瘤更容易发生更深的生长或腔外延伸。
