{Reference Type}: Journal Article
{Title}: Endoscopic resection for esophageal gastrointestinal stromal tumors: a multi-center feasibility study.
{Author}: Lian J;Ji Y;Chen T;Wang G;Wang M;Li S;Cao J;Shen L;Lu W;Xu M;
{Journal}: Therap Adv Gastroenterol
{Volume}: 17
{Issue}: 0
{Year}: 2024
{Factor}: 4.802
{DOI}: 10.1177/17562848241255304
{Abstract}: <B>UNASSIGNED: </B>Esophageal gastrointestinal stromal tumors (E-GISTs) are highly uncommon and have not been thoroughly examined.<BR><B>UNASSIGNED: </B>The objective of this multi-center study was to assess the viability of endoscopic resection (ER) in the treatment of E-GISTs and to explore its clinical implications.<BR><B>UNASSIGNED: </B>This was a multi-center retrospective study. Consecutive patients referred to the four participating centers.<BR><B>UNASSIGNED: </B>E-GISTs among the consecutive subepithelial tumors (SETs) treated by ER methods were enrolled from April 2019 to August 2022. Clinicopathological, endoscopic, and follow-up data were collected and analyzed.<BR><B>UNASSIGNED: </B>A total of 23 patients with E-GISTs were included for analysis, accounting for 1.9% of all the esophageal SETs (1243 patients). The average size of the tumor lesions was 2.3 cm (range 1.0-4.0 cm). We observed that tumors larger than 2.0 cm were more likely to grow deeper, with a statistically significant difference (p < 0.001). End bloc resection was achieved in all 23 patients. The mean operation time was 53.6 min (range 25-111 min). One patient experienced significant intraoperative bleeding, which was promptly managed endoscopically without necessitating surgery. The average hospital stay was 4.5 days (range 3-8 days). The overall median follow-up period was 31 months (range 13-47 months). No tumor recurrence, residual tumor, distal metastasis, or death was observed during the follow-up period.<BR><B>UNASSIGNED: </B>Based on our limited data, our study indicates that ER may be a feasible and effective option for treating esophageal GISTs measuring 4 cm or less. We suggest submucosal tunnel endoscopic resection as the preferred approach, as all E-GISTs in our study were situated in the muscularis propria layer. Additionally, tumors larger than 2 cm were more prone to deeper growth or extraluminal extension.