PDF(Pubmed)
Abstract：
Rodents are the largest group of mammals that adapt to different ecosystems and may act as the potential reservoirs of significant pathogens including gastrointestinal (GI) helminths. Rodent-borne parasitic pathogens have been and remain a great concern for animal and human health. The aim of this systematic review and meta-analysis is thus to clarify and better understand the pooled prevalence of GI helminthic infections and the associated risk factors in rodents in Iran. Multiple databases (PubMed, Scopus, Web of Science, Google Scholar, SID, Magiran and Irandoc) were searched for relevant literature published up to March 2022. A random-effects meta-analysis model was applied to estimate the pooled prevalence with 95 % confidence interval. Moreover, heterogeneity among studies was evaluated using the Cochran\'s Q test and the I 2-statistic. Out of the 5438 publications searched, 28 articles (30 datasets) were ultimately eligible for inclusion in the study. Thus, 3649 captured rodents belonging to 6 families, 20 genera, and 35 species were examined for GI helminths in Iran. Then, 54 helminth species were identified in the present research, including 33 nematodes, 16 cestodes, 4 trematods, and 1 acanthocephalan. The prevalence rate of GI parasitic infections was 56 % (95 % CI: 50-63 %). Hymenolepis diminuta, Syphacia obvelata and Rodentolepis nana were the most common helminthic infections (13 %, 9 %, and 8 %, respectively). Moreover, 11 potential zoonotic helminths were found. There was no significant difference in pooled prevalence between male and female rodents (P = 0.40). Considering geographical areas, northern and eastern provinces had the highest prevalence of GI helminthic infections among rodents. The prevalence of GI worms in Iranian rodents was as high as 56 % with 11 zoonotic helminths. Therefore, it is suggested to observe the health of the environment, destroy the biological nests of rodents, avoid half-finished constructions, repair and improve streams and sidewalks, organize and collect garbage, and carry out biological and chemical control to handle the population of rodents. Increasing the awareness of local people about the harmful effects of rodents and the ways of transmission and prevention of rodent-borne intestinal worms transmitted to humans should be prioritized in health decisions.
摘要：
啮齿动物是适应不同生态系统的哺乳动物的最大群体,并且可能充当重要病原体(包括胃肠(GI)蠕虫)的潜在宿主。啮齿动物传播的寄生虫病原体已经并且仍然是动物和人类健康的极大关注。因此，本系统评价和荟萃分析的目的是澄清和更好地了解伊朗啮齿动物中胃肠道蠕虫感染的合并患病率和相关风险因素。多个数据库(PubMed,Scopus,WebofScience,谷歌学者，SID,搜索了Magiran和Irandoc）直到2022年3月为止发表的相关文献。采用随机效应荟萃分析模型，以95%的置信区间估计合并患病率。此外，使用CochranQ检验和I2统计量评估研究之间的异质性。在搜索的5438种出版物中，28篇文章(30个数据集)最终符合纳入研究的条件。因此，3649只被捕获的啮齿动物属于6个家庭，20属,在伊朗检查了35种胃肠道蠕虫。然后，在本研究中发现了54种蠕虫，包括33种线虫,16节食，4个吸虫，和1个无头鱼。胃肠道寄生虫感染的患病率为56％（95％CI：50-63％）。处女膜减少，隐匿性红血病和Rodentolepisnana是最常见的蠕虫感染（13％，9%,8%,分别)。此外，发现了11种潜在的人畜共患蠕虫。男性和女性啮齿动物的合并患病率没有显着差异（P=0.40）。考虑到地理区域，在啮齿动物中,北部和东部省份的胃肠道蠕虫感染率最高.伊朗啮齿动物中胃肠道蠕虫的患病率高达56％，有11个人畜共患蠕虫。因此,建议观察环境的健康，摧毁啮齿动物的生物巢，避免半完成的建筑，修复和改善溪流和人行道，组织和收集垃圾，并进行生物和化学控制以处理啮齿动物的种群。在卫生决策中，应优先考虑提高当地人对啮齿动物的有害影响以及传播和预防啮齿动物传播的肠道蠕虫传播给人类的途径的认识。
