Abstract：
Food deprivation has been associated with the development of metabolic pathologies. Few studies have explored the repercussions of a partial food deprivation following the reestablishment of an ad libitum diet. This study investigates the impact of a partial food deprivation (an 8-hour food intake restriction coupled with a 4-hour feeding window during the active phase) and the subsequent return to ad libitum feeding on the glycemic curve, food intake, and locomotor behavior. Wistar rats aged 45 days were subjected to 6 weeks of a partial food deprivation followed by 6 weeks of ad libitum feeding. Body weight, visceral fat, food intake, circadian glycemia, oral glucose tolerance, and locomotor activity were evaluated. It was found that the partial food deprivation resulted in the reduction of both the body weight and food intake; however, it increased visceral fat by 60%. Circadian glycemic values were altered at all intervals during the light phase, and glucose sensitivity improved at 60 minutes in the oral glucose tolerance test (OGTT). In the food-deprived group, the locomotor activity rhythm was reduced, with an observed delay in the peak of activity, reduction in total activity, and a decrease in the rhythmicity percentage. After the reestablishment of the ad libitum feeding, there was recovery of body weight, no difference in visceral fat, normalization of the food intake pattern, circadian glycemia, and oral glucose tolerance. Additionally, the return to ad libitum feeding restored locomotor activity, although the duration required for its complete recovery warrants further investigation. In conclusion, partial food deprivation induces physio-metabolic changes in rats, most of which are reversed after reestablishing ad libitum feeding.
摘要：
食物匮乏与代谢病理的发展有关。很少有研究探讨在恢复随意饮食后部分食物匮乏的影响。这项研究调查了部分食物剥夺（8小时食物摄入限制加上活动阶段4小时进食窗口）以及随后恢复随意进食对血糖曲线的影响，食物摄入量,和运动行为。对45天大的Wistar大鼠进行6周的部分食物剥夺，然后进行6周的随意喂养。体重,内脏脂肪,食物摄入量,昼夜节律血糖，口服葡萄糖耐量,和运动活动进行了评估。研究发现，部分食物剥夺导致体重和食物摄入量的减少；然而，它增加了60%的内脏脂肪。在光照期的所有时间间隔内，昼夜节律血糖值都发生了变化，在口服葡萄糖耐量试验（OGTT）中，葡萄糖敏感性在60分钟时得到改善。在食物匮乏的群体中，运动活动节律降低，观察到的活动峰值延迟，总活动减少，和节律性百分比的降低。在恢复随意喂养后，体重恢复了，内脏脂肪没有区别，食物摄入模式的正常化，昼夜节律血糖，和口服葡萄糖耐量。此外,恢复随意喂养恢复了运动活动，尽管完全恢复所需的时间需要进一步调查。总之,部分食物剥夺诱导大鼠生理代谢变化，其中大多数在重新建立随意喂养后被逆转。
