关键词: antioxidant photodamage photoprotection photosensitivity ultraviolet radiation

Mesh : Humans Administration, Oral Antioxidants / administration & dosage Oxidative Stress / drug effects Reactive Oxygen Species / metabolism Skin / metabolism radiation effects drug effects Sunlight / adverse effects Ultraviolet Rays / adverse effects Protective Agents / administration & dosage

来  源:   DOI:10.1111/phpp.12985

Abstract:
BACKGROUND: Photoprotection is the first measure in the prevention and treatment of the deleterious effects that sunlight can cause on the skin. It is well known that prolonged exposure to solar radiation leads to acute and chronic complications, such as erythema, accelerated skin aging, proinflammatory and procarcinogenic effects, and eye damage, among others.
METHODS: A better understanding of the molecules that can protect against ultraviolet radiation and their effects will lead to improvements in skin health.
RESULTS: Most of these effects of the sunlight are modulated by oxidative stress and proinflammatory mechanisms, therefore, the supplementation of substances that can regulate and neutralize reactive oxygen species would be beneficial for skin protection. Current evidence indicates that systemic photoprotection should be used as an adjunctive measure to topical photoprotection.
CONCLUSIONS: Oral photoprotectors are a promising option in improving protection against damage induced by UVR, as they contain active ingredients that increase the antioxidant effects of the body, complementing other photoprotection measures. We present a review of oral photoprotectors and their effects.
摘要:
背景:光保护是预防和治疗阳光可能对皮肤造成的有害影响的第一个措施。众所周知,长时间暴露于太阳辐射会导致急性和慢性并发症,如红斑,加速皮肤老化,促炎和前致癌作用,和眼睛损伤,在其他人中。
方法:更好地了解可以防止紫外线辐射的分子及其作用将导致皮肤健康的改善。
结果:阳光的这些作用大部分受氧化应激和促炎机制的调节,因此,补充可以调节和中和活性氧的物质将有利于皮肤保护。目前的证据表明,全身光保护应用作局部光保护的辅助措施。
结论:口腔光保护剂是一种有前途的选择,可以改善对紫外线照射损伤的保护作用,因为它们含有增加身体抗氧化作用的活性成分,补充其他光保护措施。我们对口腔光保护剂及其作用进行了综述。
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