Abstract：
UNASSIGNED: Little is known about the association between whole-blood nicotinamide adenine dinucleotide (NAD +) levels and nabothian cysts. This study aimed to assess the association between NAD + levels and nabothian cysts in healthy Chinese women.
UNASSIGNED: Multivariate logistic regression analysis was performed to analyze the association between NAD + levels and nabothian cysts.
UNASSIGNED: The mean age was 43.0 ± 11.5 years, and the mean level of NAD + was 31.3 ± 5.3 μmol/L. Nabothian cysts occurred in 184 (27.7%) participants, with single and multiple cysts in 100 (15.0%) and 84 (12.6%) participants, respectively. The total nabothian cyst prevalence gradually decreased from 37.4% to 21.6% from Q1 to Q4 of NAD + and the prevalence of single and multiple nabothian cysts also decreased across the NAD + quartiles. As compared with the highest NAD + quartile (≥ 34.4 μmol/L), the adjusted odds ratios with 95% confidence interval of the NAD + Q1 was 1.89 (1.14-3.14) for total nabothian cysts. The risk of total and single nabothian cysts linearly decreased with increasing NAD + levels, while the risk of multiple nabothian cysts decreased more rapidly at NAD + levels of 28.0 to 35.0 μmol/L.
UNASSIGNED: Low NAD + levels were associated with an increased risk of total and multiple nabothian cysts.
UNASSIGNED: Multivariate logistic regression analysis was performed to analyze the association between NAD + levels and nabothian cysts.
UNASSIGNED: The mean age was 43.0 ± 11.5 years, and the mean level of NAD + was 31.3 ± 5.3 μmol/L. Nabothian cysts occurred in 184 (27.7%) participants, with single and multiple cysts in 100 (15.0%) and 84 (12.6%) participants, respectively. The total nabothian cyst prevalence gradually decreased from 37.4% to 21.6% from Q1 to Q4 of NAD + and the prevalence of single and multiple nabothian cysts also decreased across the NAD + quartiles. As compared with the highest NAD + quartile (≥ 34.4 μmol/L), the adjusted odds ratios with 95% confidence interval of the NAD + Q1 was 1.89 (1.14-3.14) for total nabothian cysts. The risk of total and single nabothian cysts linearly decreased with increasing NAD + levels, while the risk of multiple nabothian cysts decreased more rapidly at NAD + levels of 28.0 to 35.0 μmol/L.
UNASSIGNED: Low NAD + levels were associated with an increased risk of total and multiple nabothian cysts.
摘要：
■关于全血烟酰胺腺嘌呤二核苷酸(NAD+)水平与纳贝囊肿之间的关联知之甚少。本研究旨在评估中国健康女性NAD+水平与纳博托囊肿之间的关系。
■采用多因素logistic回归分析NAD+水平与纳博培囊肿的相关性。
■平均年龄为43.0±11.5岁，NAD+的平均水平为31.3±5.3μmol/L。Nabothian囊肿发生在184名（27.7％）参与者中，100名（15.0%）和84名（12.6%）参与者中有单个和多个囊肿，分别。从NAD的Q1到Q4，纳博代囊肿的总患病率从37.4％逐渐下降到21.6％，单个和多个纳博代囊肿的患病率在NAD四分位数中也有所下降。与最高NAD+四分位数(≥34.4μmol/L)相比，NAD+Q1的95%置信区间的校正比值比为1.89(1.14~3.14).随着NAD+水平的增加，总囊肿和单囊肿的风险线性降低，而在28.0至35.0μmol/L的NAD水平下，多发性纳博代囊肿的风险降低更快。
■低NAD+水平与总的和多个纳博托囊肿的风险增加相关。
■采用多因素logistic回归分析NAD+水平与纳博培囊肿的相关性。
■平均年龄为43.0±11.5岁，NAD+的平均水平为31.3±5.3μmol/L。Nabothian囊肿发生在184名（27.7％）参与者中，100名（15.0%）和84名（12.6%）参与者中有单个和多个囊肿，分别。从NAD的Q1到Q4，纳博代囊肿的总患病率从37.4％逐渐下降到21.6％，单个和多个纳博代囊肿的患病率在NAD四分位数中也有所下降。与最高NAD+四分位数(≥34.4μmol/L)相比，NAD+Q1的95%置信区间的校正比值比为1.89(1.14~3.14).随着NAD+水平的增加，总囊肿和单囊肿的风险线性降低，而在28.0至35.0μmol/L的NAD水平下，多发性纳博代囊肿的风险降低更快。
■低NAD+水平与总的和多个纳博托囊肿的风险增加相关。
