Abstract：
Phosphoinositides (PtdIns) are a family of differentially phosphorylated lipid second messengers localized to the cytoplasmic leaflet of both plasma and intracellular membranes. Kinases and phosphatases can selectively modify the PtdIns composition of different cellular compartments, leading to the recruitment of specific binding proteins, which control cellular homeostasis and proliferation. Thus, while PtdIns affect cell growth and survival during interphase, they are also emerging as key drivers in multiple temporally defined membrane remodeling events of mitosis, like cell rounding, spindle orientation, cytokinesis, and abscission. In this review, we summarize and discuss what is known about PtdIns function during mitosis and how alterations in the production and removal of PtdIns can interfere with proper cell division.
摘要：
磷酸肌醇（PtdIns）是位于血浆和细胞内膜的细胞质小叶的差异磷酸化脂质第二信使家族。激酶和磷酸酶可以选择性地改变不同细胞区室的PtdIns组成，导致特异性结合蛋白的募集，控制细胞稳态和增殖。因此，虽然PtdIns在间期影响细胞生长和存活，它们也正在成为多个时间定义的有丝分裂膜重塑事件的关键驱动因素，像单元格四舍五入，主轴方向,胞质分裂,和脱落。在这次审查中,我们总结并讨论了有丝分裂过程中PtdIns功能的已知情况，以及PtdIns产生和去除的变化如何干扰适当的细胞分裂。
