ARK2N - CK2 复合物通过增强 CSB 与病变停滞的 RNAPII 的相互作用来启动转录偶联修复。
关键词: ARK2N CK2 CSB Cockayne syndrome transcription-coupled nucleotide excision repair
Mesh : DNA Repair Enzymes / metabolism genetics RNA Polymerase II / metabolism genetics Poly-ADP-Ribose Binding Proteins / metabolism genetics Humans Animals Mice DNA Repair DNA Helicases / metabolism genetics Cockayne Syndrome / genetics metabolism Transcription, Genetic Phosphorylation Casein Kinase II / metabolism genetics Mice, Knockout DNA Damage ATPases Associated with Diverse Cellular Activities / metabolism genetics Chromatin / metabolism Ubiquitination Excision Repair
来 源:
DOI:10.1073/pnas.2404383121
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