PDF(Pubmed)
Abstract：
UNASSIGNED: To evaluate microvascular intereye differences in diabetic patients with same-stage diabetic retinopathy (DR) in both eyes as assessed using optical coherence tomography angiography (OCTA).
UNASSIGNED: In this cross-sectional study, fovea-centered swept-source 6 × 6 mm OCTA scans were acquired using a 200 kHz OCTA device. Vessel density (VD) and fractal dimension were calculated on binarized, vessel-segmented images in the superficial capillary plexus (SCP) and deep capillary plexus (DCP). Foveal avascular zone (FAZ) area (FAZA) and perimeter (FAZP) was measured and FAZ circularity (FAZC) calculated. Absolute difference (δabs) and asymmetry index between eyes was assessed and compared across DR stages. Differences of VD, FD, and FAZ parameters between left and right eye were evaluated using linear mixed models.
UNASSIGNED: A total of 336 eyes of 168 diabetic patients without DR and with DR stages ranging from mild nonproliferative to proliferative DR were included for analysis. The intereye comparison revealed significantly lower VD in the SCP (estimate [95% CI] = -0.009 [-0.01; -0.006], P < 0.01), as well as a significantly lower FD in the SCP (-0.007 [-0.009; -0.005], P < 0.01) of the left compared to the right eye. FAZC of the left compared to the right eye was lower in eyes without DR, moderate DR, and PDR (P < 0.05). FAZ δabs and asymmetry index were higher in more advanced disease stages (P < 0.05).
UNASSIGNED: OCTA metrics provide important information on the retinal microvasculature in systemic diseases such as DR. Our results reveal a significant intereye difference with lower VD and FD in the SCP as well as higher FAZ impairment of the left compared to the right eye.
UNASSIGNED: In this cross-sectional study, fovea-centered swept-source 6 × 6 mm OCTA scans were acquired using a 200 kHz OCTA device. Vessel density (VD) and fractal dimension were calculated on binarized, vessel-segmented images in the superficial capillary plexus (SCP) and deep capillary plexus (DCP). Foveal avascular zone (FAZ) area (FAZA) and perimeter (FAZP) was measured and FAZ circularity (FAZC) calculated. Absolute difference (δabs) and asymmetry index between eyes was assessed and compared across DR stages. Differences of VD, FD, and FAZ parameters between left and right eye were evaluated using linear mixed models.
UNASSIGNED: A total of 336 eyes of 168 diabetic patients without DR and with DR stages ranging from mild nonproliferative to proliferative DR were included for analysis. The intereye comparison revealed significantly lower VD in the SCP (estimate [95% CI] = -0.009 [-0.01; -0.006], P < 0.01), as well as a significantly lower FD in the SCP (-0.007 [-0.009; -0.005], P < 0.01) of the left compared to the right eye. FAZC of the left compared to the right eye was lower in eyes without DR, moderate DR, and PDR (P < 0.05). FAZ δabs and asymmetry index were higher in more advanced disease stages (P < 0.05).
UNASSIGNED: OCTA metrics provide important information on the retinal microvasculature in systemic diseases such as DR. Our results reveal a significant intereye difference with lower VD and FD in the SCP as well as higher FAZ impairment of the left compared to the right eye.
摘要：
■评估使用光学相干断层扫描血管造影（OCTA）评估的双眼患有同期糖尿病视网膜病变（DR）的糖尿病患者的微血管间差异。
■在这项横断面研究中，使用200kHzOCTA设备获取中心凹的扫频源6×6mmOCTA扫描。血管密度(VD)和分形维数在二值化计算，浅表毛细血管丛（SCP）和深毛细血管丛（DCP）的血管分割图像。测量中心凹无血管区(FAZ)面积(FAZA)和周长(FAZP)并计算FAZ圆度(FAZC)。评估并比较了不同DR分期的眼睛之间的绝对差异（δabs）和不对称指数。VD的差异，FD,使用线性混合模型评估左眼和右眼之间的FAZ参数。
■共纳入168例糖尿病患者的336只眼进行分析，这些患者的DR分期从轻度非增生到增生性DR不等。intereye比较显示SCP中的VD显著降低(估计[95%CI]=-0.009[-0.01;-0.006],P<0.01),以及SCP中明显较低的FD（-0.007[-0.009;-0.005]，与右眼相比，左眼的P<0.01）。在没有DR的眼中，左眼的FAZC低于右眼，中度DR,和PDR(P<0.05)。在更晚期的疾病阶段，FAZδabs和不对称指数更高（P<0.05）。
■OCTA指标提供了有关DR等全身性疾病中视网膜微脉管系统的重要信息。我们的结果表明，与右眼相比，SCP的VD和FD较低，而左眼的FAZ损害较高，这两者之间存在显着差异。
■在这项横断面研究中，使用200kHzOCTA设备获取中心凹的扫频源6×6mmOCTA扫描。血管密度(VD)和分形维数在二值化计算，浅表毛细血管丛（SCP）和深毛细血管丛（DCP）的血管分割图像。测量中心凹无血管区(FAZ)面积(FAZA)和周长(FAZP)并计算FAZ圆度(FAZC)。评估并比较了不同DR分期的眼睛之间的绝对差异（δabs）和不对称指数。VD的差异，FD,使用线性混合模型评估左眼和右眼之间的FAZ参数。
■共纳入168例糖尿病患者的336只眼进行分析，这些患者的DR分期从轻度非增生到增生性DR不等。intereye比较显示SCP中的VD显著降低(估计[95%CI]=-0.009[-0.01;-0.006],P<0.01),以及SCP中明显较低的FD（-0.007[-0.009;-0.005]，与右眼相比，左眼的P<0.01）。在没有DR的眼中，左眼的FAZC低于右眼，中度DR,和PDR(P<0.05)。在更晚期的疾病阶段，FAZδabs和不对称指数更高（P<0.05）。
■OCTA指标提供了有关DR等全身性疾病中视网膜微脉管系统的重要信息。我们的结果表明，与右眼相比，SCP的VD和FD较低，而左眼的FAZ损害较高，这两者之间存在显着差异。
