关键词: Cushing's Disease Endoscopic Nuances Selective adenomectomy Trans-sphenoidal, technique

Mesh : Humans Adenoma / surgery diagnostic imaging Pituitary ACTH Hypersecretion / surgery Endoscopy / methods ACTH-Secreting Pituitary Adenoma / surgery Pituitary Neoplasms / surgery diagnostic imaging Neuroendoscopy / methods Treatment Outcome Neurosurgical Procedures / methods Female Sphenoid Bone / surgery

来  源:   DOI:10.1007/s00701-024-06078-y   PDF(Pubmed)

Abstract:
BACKGROUND: An ACTH-secreting pituitary adenoma is the most common cause of excessive endogenous glucocorticoid production resulting in Cushing\'s Syndrome. A multidisciplinary approach is paramount. Selective adenomectomy is the treatment of choice.
METHODS: Endoscopic transnasal transsphenoidal approach to the tumour, along with techniques for resection, are demonstrated.
CONCLUSIONS: Endoscopic transsphenoidal approaches with its magnified view of the pituitary gland allows precise microsurgical dissection during selective adenomectomy. This technique increases the possibility of proving a gross total resection, leading to clinical and biochemical cure in these patients.
摘要:
背景:分泌ACTH的垂体腺瘤是导致库欣综合征的内源性糖皮质激素产生过多的最常见原因。多学科方法至关重要。选择性腺瘤切除术是首选治疗方法。
方法:鼻内镜经鼻蝶入路肿瘤,以及切除技术,被证明。
结论:内镜经鼻蝶入路放大了垂体腺体,可以在选择性腺瘤切除术中进行精确的显微外科解剖。这种技术增加了证明总切除的可能性,导致这些患者的临床和生化治愈。
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