Abstract：
Background With the rise in cosmetic usage, adverse reactions related to cosmetics have also risen. Photocontact dermatitis to cosmetics is a challenging entity to diagnose and manage. Objectives To evaluate the clinical features and photocontact sensitivity patterns in patients with cosmetic dermatitis and establish their association based on patch and photopatch test results. Methods A prospective observational study, where 80 patients with a clinical diagnosis of cosmetic dermatitis were patch or photopatch tested (as per indication) with the Indian standard series, Indian cosmetic and fragrance series, and the patient\'s personal product(s). Results A total of 104 positive reactions were observed in 57/80 patients, of which 50 were relevant to cosmetics usage. Sixty-five patients underwent a photopatch test, and 17 tested positive. Photosensitivity in patients was significantly associated with a positive photopatch test (p-value < 0.001). Various new photo-allergens were discovered, including propylene glycol, triethanolamine, chloroacetamide, isopropyl myristate, cetrimide and hexamine. Facial melanosis was a predominant clinical finding in 44 patients, with pigmented contact dermatitis detected in 19 (43.2%) of these cases. Limitations Patients\' personal products could not be tested on every patient. Chemical analysis of indigenous products and the individual chemical ingredients of the patient\'s personal products could not be patch-tested separately. Phototesting was not performed in patients with photosensitivity. Conclusion In patients with suspected cosmetic dermatitis with history of photosensitivity or those with facial melanosis of unknown origin, a photopatch test is crucial to detect potentially hidden photo allergens. Many new photo allergens have emerged in the present study. Cosmetic companies should provide detailed information regarding each constituent of the cosmetic products.
摘要：
背景技术随着化妆品使用的增加,与化妆品有关的不良反应也有所增加。对化妆品的光接触性皮炎是诊断和管理的挑战性实体。目的评估化妆品性皮炎患者的临床特征和光接触敏感性模式，并根据贴片和光配对测试结果建立其相关性。方法前瞻性观察性研究,其中80名临床诊断为化妆品皮炎的患者接受了印度标准系列的贴片或照相测试（根据适应症），印度化妆品和香水系列，以及患者的个人产品。结果57/80例患者共观察到104例阳性反应，其中50与化妆品使用有关。六十五名病人接受了照样试验,17人检测呈阳性.患者的光敏性与光合试验阳性显著相关(p值<0.001)。各种新的光过敏原被发现，包括丙二醇，三乙醇胺,氯乙酰胺，肉豆蔻酸异丙酯,西曲溴胺和六胺。面部黑变病是44例患者的主要临床发现，在这些病例中，有19例（43.2％）发现了色素性接触性皮炎。限制患者的个人产品无法在每个患者身上进行测试。本土产品的化学分析和患者个人产品的单个化学成分不能单独进行贴片测试。光敏性患者未进行光测试。结论怀疑有光敏性病史的化妆品性皮炎患者或不明原因的面部黑变病患者,photopatch测试对于检测潜在隐藏的照片过敏原至关重要。本研究中出现了许多新的照片过敏原。化妆品公司应提供有关化妆品产品各成分的详细信息。
