Abstract：
In order to improve the effectiveness of tumor treatment and reduce the toxic side effects of drugs, we formed carrier-free multifunctional nanoparticles (BI NPs) by noncovalent interaction of berberine hydrochloride and IR780. BI NPs possessed the synergistic effects of promoting apoptosis, inhibiting proliferation and metastasis of tumors, and phototherapeutic treatment. Dispersive and passive targeting ability retention (EPR) effects of BI NPs on tumor sites in vivo could be monitored by fluorescence imaging. In addition, BI NPs exhibited effective reactive oxygen species (ROS) generation and photothermal conversion capabilities, photodynamic therapy (PDT), and photothermal therapy (PTT). Importantly, BI NPs inhibit tumor suppression through the AMPK/PI3K/AKT signaling pathway to inhibit tumor proliferation and metastasis. BI NPs not only have efficient in vivo multimodal therapeutic effects but also have good biosafety and potential clinical applications.
摘要：
为了提高肿瘤治疗的有效性,减少药物的毒副作用,我们通过盐酸小檗碱和IR780的非共价相互作用形成了无载体多功能纳米颗粒（BINP）。BINP具有促进细胞凋亡的协同作用，抑制肿瘤的增殖和转移，和光疗治疗。可以通过荧光成像监测BINPs在体内对肿瘤部位的分散和被动靶向能力保留(EPR)效应。此外,BINP表现出有效的活性氧（ROS）产生和光热转化能力，光动力疗法（PDT），和光热疗法（PTT）。重要的是,BINPs通过AMPK/PI3K/AKT信号通路抑制肿瘤抑制，从而抑制肿瘤增殖和转移。BINPs不仅具有有效的体内多模式治疗效果，而且具有良好的生物安全性和潜在的临床应用。
