PDF(Pubmed)
Abstract：
BACKGROUND: Gut dysbiosis has been established as a characteristic of schizophrenia (SCH). However, the signatures regarding SCH patients with prominent negative symptoms (SCH-N) in young adults have been poorly elucidated.
METHODS: Stool samples were obtained from 30 young adults with SCH-N, 32 SCH patients with prominent positive symptoms (SCH-P) along with 36 healthy controls (HCs). Microbial diversity and composition were analyzed by 16S rRNA gene sequencing. Meanwhile, psychiatric symptoms were assessed by the positive and negative syndrome scale (PANSS).
RESULTS: There is a significant difference in β-diversity but not α-diversity indexes among the three groups. Moreover, we found a higher abundance of Fusobacteria and Proteobacteria phyla and a lower abundance of Firmicutes phyla in SCH-N when compared with HC. Besides, we identified a diagnostic potential panel comprising six genera (Coprococcus, Monoglobus, Prevotellaceae_NK3B31_group, Escherichia-Shigella, Dorea, and Butyricicoccus) that can distinguish SCH-N from HC (area under the curve = 0.939). However, the difference in microbial composition between the SCH-N and SCH-P is much less than that between SCH-N and the HC, and SCH-N and SCH-P cannot be effectively distinguished by gut microbiota.
CONCLUSIONS: The composition of gut microbiota was changed in the patients with SCH-N, which may help in further understanding of pathogenesis in young adults with SCH-N.
METHODS: Stool samples were obtained from 30 young adults with SCH-N, 32 SCH patients with prominent positive symptoms (SCH-P) along with 36 healthy controls (HCs). Microbial diversity and composition were analyzed by 16S rRNA gene sequencing. Meanwhile, psychiatric symptoms were assessed by the positive and negative syndrome scale (PANSS).
RESULTS: There is a significant difference in β-diversity but not α-diversity indexes among the three groups. Moreover, we found a higher abundance of Fusobacteria and Proteobacteria phyla and a lower abundance of Firmicutes phyla in SCH-N when compared with HC. Besides, we identified a diagnostic potential panel comprising six genera (Coprococcus, Monoglobus, Prevotellaceae_NK3B31_group, Escherichia-Shigella, Dorea, and Butyricicoccus) that can distinguish SCH-N from HC (area under the curve = 0.939). However, the difference in microbial composition between the SCH-N and SCH-P is much less than that between SCH-N and the HC, and SCH-N and SCH-P cannot be effectively distinguished by gut microbiota.
CONCLUSIONS: The composition of gut microbiota was changed in the patients with SCH-N, which may help in further understanding of pathogenesis in young adults with SCH-N.
摘要：
背景：肠道菌群失调已被确定为精神分裂症（SCH）的特征。然而,关于年轻成人中具有突出阴性症状(SCH-N)的SCH患者的特征尚不清楚.
方法：从30名患有SCH-N的年轻人中获得粪便样本，32名显著阳性症状(SCH-P)的SCH患者和36名健康对照(HC)。通过16SrRNA基因测序分析微生物多样性和组成。同时,通过阳性和阴性综合征量表(PANSS)评估精神症状.
结果：三组之间的β多样性指数存在显着差异，但α多样性指数没有显着差异。此外，与HC相比，我们发现SCH-N中的Fusobacteria和Proteobacteriaphyla的丰度更高，而Firmicutesphyla的丰度更低。此外,我们确定了一个由六个属组成的诊断潜力小组(球菌，Monoglobus,Prevotellaceae_NK3B31_组，大肠杆菌志贺氏菌,Dorea,和Butyricicocus）可以区分SCH-N和HC（曲线下面积=0.939）。然而,SCH-N和SCH-P之间的微生物组成差异远小于SCH-N和HC之间的差异，SCH-N和SCH-P不能通过肠道微生物群有效区分。
结论：SCH-N患者的肠道菌群组成发生改变，这可能有助于进一步了解年轻成人SCH-N的发病机制。
方法：从30名患有SCH-N的年轻人中获得粪便样本，32名显著阳性症状(SCH-P)的SCH患者和36名健康对照(HC)。通过16SrRNA基因测序分析微生物多样性和组成。同时,通过阳性和阴性综合征量表(PANSS)评估精神症状.
结果：三组之间的β多样性指数存在显着差异，但α多样性指数没有显着差异。此外，与HC相比，我们发现SCH-N中的Fusobacteria和Proteobacteriaphyla的丰度更高，而Firmicutesphyla的丰度更低。此外,我们确定了一个由六个属组成的诊断潜力小组(球菌，Monoglobus,Prevotellaceae_NK3B31_组，大肠杆菌志贺氏菌,Dorea,和Butyricicocus）可以区分SCH-N和HC（曲线下面积=0.939）。然而,SCH-N和SCH-P之间的微生物组成差异远小于SCH-N和HC之间的差异，SCH-N和SCH-P不能通过肠道微生物群有效区分。
结论：SCH-N患者的肠道菌群组成发生改变，这可能有助于进一步了解年轻成人SCH-N的发病机制。
