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Abstract：
UNASSIGNED: This study aims to investigate the differences in binocular corneal parameters and their interrelation with binocular biometric parameters asymmetry in patients with simple myopic anisometropia, thereby elucidating the influence of myopia process on various corneal parameters.
UNASSIGNED: In this cross-sectional study, 65 patients with anisometropia in monocular myopia were included. They were divided into low anisometropia group: 3.00D<Δ spherical equivalent (SE)≤-1.00D (Δ represents the difference between the two eyes, i.e., myopic data minus emmetropic data) and high anisometropia group: ΔSE ≤ -3.00D. Corneal and ocular biometric parameters were measured using Pentacam, Corvis ST, and IOL Master 700. Statistical analyses focused on the binocular corneal parameters asymmetry, using the contralateral emmetropia as a control.
UNASSIGNED: The mean age of participants was 18.5 ± 1.3 years, with the average SE for myopia and emmetropia being -2.93 ± 1.09D and -0.16 ± 0.41D, respectively. The central corneal thickness (CCT), flat keratometry (Kf), keratometry astigmatism (Ka), total corneal aberration (6 mm) (TOA), surface variance index (ISV), vertical asymmetry index (IVA), stress-strain index (SSI), and first applanation stiffness parameter (SPA1) and ambrosia relational thickness-horizontal (ARTh) showed significant differences between anisometropic fellow eyes (p < 0.05). There were significant differences in ΔIVA, Δ the difference between the mean refractive power of the inferior and superior corneas (I-S), Δ deviation value of Belin/Ambrósio enhanced ectasia display (BAD-D), Δ deformation amplitude ratio max (2 mm) (DAR)and Δ tomographic biomechanical index (TBI) (p < 0.05) in two groups. Asymmetry of corneal parameters was correlated with asymmetry of ocular biometric parameters. Anisometropia (ΔSE) was positively correlated with ΔIVA (r = 0.255, p = 0.040), ΔBAD-D (r = 0.360, p = 0.006), and ΔSSI (r = 0.276, p = 0.039) and negatively correlated with ΔDAR (r = -0.329, p = 0.013) in multiple regression analysis. Δ mean keratometry (Km), Δ anterior chamber depth (ACD), and Δ biomechanically corrected intraocular pressure (bIOP) were also associated with binocular corneal differences.
UNASSIGNED: Compared to contralateral emmetropia, myopic eyes have thinner corneas and smaller corneal astigmatism. Myopic corneas exhibit relatively more regular surface morphology but are more susceptible to deformation and possess marginally inferior biomechanical properties. In addition, there is a certain correlation between anisometropia and corneal parameter asymmetry, which would be instrumental in predicting the development of myopia.
UNASSIGNED: In this cross-sectional study, 65 patients with anisometropia in monocular myopia were included. They were divided into low anisometropia group: 3.00D<Δ spherical equivalent (SE)≤-1.00D (Δ represents the difference between the two eyes, i.e., myopic data minus emmetropic data) and high anisometropia group: ΔSE ≤ -3.00D. Corneal and ocular biometric parameters were measured using Pentacam, Corvis ST, and IOL Master 700. Statistical analyses focused on the binocular corneal parameters asymmetry, using the contralateral emmetropia as a control.
UNASSIGNED: The mean age of participants was 18.5 ± 1.3 years, with the average SE for myopia and emmetropia being -2.93 ± 1.09D and -0.16 ± 0.41D, respectively. The central corneal thickness (CCT), flat keratometry (Kf), keratometry astigmatism (Ka), total corneal aberration (6 mm) (TOA), surface variance index (ISV), vertical asymmetry index (IVA), stress-strain index (SSI), and first applanation stiffness parameter (SPA1) and ambrosia relational thickness-horizontal (ARTh) showed significant differences between anisometropic fellow eyes (p < 0.05). There were significant differences in ΔIVA, Δ the difference between the mean refractive power of the inferior and superior corneas (I-S), Δ deviation value of Belin/Ambrósio enhanced ectasia display (BAD-D), Δ deformation amplitude ratio max (2 mm) (DAR)and Δ tomographic biomechanical index (TBI) (p < 0.05) in two groups. Asymmetry of corneal parameters was correlated with asymmetry of ocular biometric parameters. Anisometropia (ΔSE) was positively correlated with ΔIVA (r = 0.255, p = 0.040), ΔBAD-D (r = 0.360, p = 0.006), and ΔSSI (r = 0.276, p = 0.039) and negatively correlated with ΔDAR (r = -0.329, p = 0.013) in multiple regression analysis. Δ mean keratometry (Km), Δ anterior chamber depth (ACD), and Δ biomechanically corrected intraocular pressure (bIOP) were also associated with binocular corneal differences.
UNASSIGNED: Compared to contralateral emmetropia, myopic eyes have thinner corneas and smaller corneal astigmatism. Myopic corneas exhibit relatively more regular surface morphology but are more susceptible to deformation and possess marginally inferior biomechanical properties. In addition, there is a certain correlation between anisometropia and corneal parameter asymmetry, which would be instrumental in predicting the development of myopia.
摘要：
■本研究旨在探讨单纯性近视性屈光参差患者双眼角膜参数的差异及其与双眼生物参数不对称性的相互关系，从而阐明近视过程对各种角膜参数的影响。
■在这项横断面研究中，纳入单眼近视性屈光参差患者65例。他们被分为低屈光参差组：3.00D<Δ等效球形（SE）≤-1.00D（Δ代表两只眼睛之间的差异，即，近视数据减去正视数据）和高屈光参差组：ΔSE≤-3.00D。使用Pentacam测量角膜和眼部生物特征参数，科维斯ST,IOLMaster700.统计分析集中在双眼角膜参数不对称性上，使用对侧正视作为对照。
■参与者的平均年龄为18.5±1.3岁，近视和正视的平均SE为-2.93±1.09D和-0.16±0.41D，分别。中央角膜厚度（CCT），平面角膜曲率测量（Kf），角膜曲率测量散光（Ka），总角膜像差（6mm）（TOA），表面方差指数(ISV)，垂直不对称指数(IVA)，应力-应变指数（SSI），第一压平刚度参数（SPA1）和羊角关系厚度-水平（ARTh）在屈光参差的同眼之间显示出显着差异（p<0.05）。ΔIVA有显著差异,Δ下角膜和上角膜（I-S）的平均屈光力之差，Belin/Ambrósio增强扩张显示的Δ偏差值（BAD-D），两组的Δ变形幅度比max（2mm）（DAR）和Δ断层生物力学指数（TBI）（p<0.05）。角膜参数的不对称性与眼部生物特征参数的不对称性相关。屈光参差(ΔSE)与ΔIVA呈正相关(r=0.255,p=0.040),ΔBAD-D（r=0.360，p=0.006），在多元回归分析中，ΔSSI（r=0.276，p=0.039）与ΔDAR（r=-0.329，p=0.013）呈负相关。Δ平均角膜曲率（Km），Δ前房深度（ACD），和Δ生物力学校正的眼内压（bIOP）也与双眼角膜差异有关。
■与对侧正视相比，近视眼角膜较薄，角膜散光较小。近视角膜表现出相对更规则的表面形态，但更容易变形，并具有较差的生物力学特性。此外,屈光参差与角膜参数不对称性有一定的相关性,这将有助于预测近视的发展。
■在这项横断面研究中，纳入单眼近视性屈光参差患者65例。他们被分为低屈光参差组：3.00D<Δ等效球形（SE）≤-1.00D（Δ代表两只眼睛之间的差异，即，近视数据减去正视数据）和高屈光参差组：ΔSE≤-3.00D。使用Pentacam测量角膜和眼部生物特征参数，科维斯ST,IOLMaster700.统计分析集中在双眼角膜参数不对称性上，使用对侧正视作为对照。
■参与者的平均年龄为18.5±1.3岁，近视和正视的平均SE为-2.93±1.09D和-0.16±0.41D，分别。中央角膜厚度（CCT），平面角膜曲率测量（Kf），角膜曲率测量散光（Ka），总角膜像差（6mm）（TOA），表面方差指数(ISV)，垂直不对称指数(IVA)，应力-应变指数（SSI），第一压平刚度参数（SPA1）和羊角关系厚度-水平（ARTh）在屈光参差的同眼之间显示出显着差异（p<0.05）。ΔIVA有显著差异,Δ下角膜和上角膜（I-S）的平均屈光力之差，Belin/Ambrósio增强扩张显示的Δ偏差值（BAD-D），两组的Δ变形幅度比max（2mm）（DAR）和Δ断层生物力学指数（TBI）（p<0.05）。角膜参数的不对称性与眼部生物特征参数的不对称性相关。屈光参差(ΔSE)与ΔIVA呈正相关(r=0.255,p=0.040),ΔBAD-D（r=0.360，p=0.006），在多元回归分析中，ΔSSI（r=0.276，p=0.039）与ΔDAR（r=-0.329，p=0.013）呈负相关。Δ平均角膜曲率（Km），Δ前房深度（ACD），和Δ生物力学校正的眼内压（bIOP）也与双眼角膜差异有关。
■与对侧正视相比，近视眼角膜较薄，角膜散光较小。近视角膜表现出相对更规则的表面形态，但更容易变形，并具有较差的生物力学特性。此外,屈光参差与角膜参数不对称性有一定的相关性,这将有助于预测近视的发展。
