PDF(Pubmed)
Abstract：
Antimicrobial agents are widely used, and drug interactions are challenging due to increased risk of adverse effects or reduced efficacy. Among the interactions, the most important are those affecting metabolism, although those involving drug transporters are becoming increasingly known. To make clinical decisions, it is key to know the intensity of the interaction, as well as its duration and time-dependent recovery after discontinuation of the causative agents. It is not only important to be aware of all patient treatments, but also of supplements and natural medications that may also interact. Although they can have serious consequences, most interactions can be adequately managed with a good understanding of them. Especially in patients with polipharmacy it is compulsory to check them with an electronic clinical decision support database. This article aims to conduct a narrative review focusing on the major clinically significant pharmacokinetic drug-drug interactions that can be seen in patients receiving treatment for bacterial infections.
摘要：
抗菌剂被广泛使用,由于不良反应风险增加或疗效降低，药物相互作用具有挑战性。在互动中，最重要的是那些影响新陈代谢的物质，尽管那些涉及药物转运蛋白的人越来越为人所知。为了做出临床决定，知道互动的强度是关键，以及中断病原体后的持续时间和时间依赖性恢复。了解所有患者的治疗方法不仅重要，而且补充剂和天然药物也可能相互作用。虽然会带来严重的后果,大多数互动都可以通过对它们有很好的理解来得到充分的管理。特别是在患有政治药物的患者中，必须使用电子临床决策支持数据库对其进行检查。本文旨在进行叙述性综述，重点是在接受细菌感染治疗的患者中可以看到的主要临床上有意义的药代动力学药物-药物相互作用。
