Abstract：
Azoles have long been regarded as an ideal scaffold for the development of numerous innovative therapeutic agents as well as other incredibly adaptable and beneficial chemicals with prospective uses in a variety of fields, including materials, energetics (explosophores), and catalysis (azole organocatalytic arbitration). Azoles exhibit promising pharmacological activities, including antimicrobial, antidiabetic, antiviral, antidepressant, antihistaminic, antitumor, antioxidant, antiallergic, antihelmintic, and antihypertensive activity. According to a database analysis of U.S. FDAapproved medications, 59% of specific medications are connected to small molecules that have heterocycles having nitrogen atoms. The azole moiety has impressive electron abundance. Azoles promptly attach to various receptors as well as enzymes in the physiological environment via distinct specialized interactions, contributing to their anti-diabetic potential. This review encompasses the recent research progress on potent azole-derived antidiabetic agents that can be used as an alternative for the management of type-2 diabetes.
摘要：
长期以来，唑类一直被认为是开发许多创新治疗剂以及其他令人难以置信的适应性和有益的化学物质的理想支架，这些化学物质具有在各个领域的潜在用途。包括材料,能量学（探索者），和催化(唑类有机催化仲裁)。唑类表现出有希望的药理活性，包括抗菌药物,抗糖尿病药,抗病毒，抗抑郁药,抗组胺药,抗肿瘤，抗氧化剂，抗过敏,反蠕虫,和抗高血压活性。根据对美国FDA批准的药物的数据库分析，59%的特定药物与具有含氮原子的杂环的小分子有关。唑部分具有令人印象深刻的电子丰度。唑类在生理环境中通过独特的特殊相互作用迅速附着于各种受体和酶，有助于他们的抗糖尿病潜力。本文综述了近年来关于唑类药物衍生的抗糖尿病药物的研究进展，这些药物可用于治疗2型糖尿病。
