PDF(Pubmed)
Abstract：
Exhaust emissions, which count among the most common causes of premature death worldwide, can cause irreversible changes in cells, leading to their damage or degeneration. In this research, L929 line cells were observed after exposure in the BAT-CELL chamber to exhaust gases emitted from a Euro 6 compression-ignition engine. Real road traffic conditions were simulated, taking into account air resistance while driving at speeds of 50 km/h, 120 km/h and idling engine. Morphological analysis of the cells was performed using an environmental scanning electron microscope. It has been observed that diesel exhaust fumes can cause inflammation, which can induce apoptosis or leads to necrotic cell death. The impact of the vehicle exhaust gases can inhibit cell proliferation by almost three times. Moreover, a correlation has been observed between the speed of the inflammatory reaction in cells and the presence of specific hydrocarbon compounds that determine the toxicity of exhaust gases. Research has shown that the toxicity of the emitted exhaust gases has been the highest at the driving speed of 120 km/h. In order to reduce the harmful effects of exhaust emissions, ecological alternatives and the supplementation of legal provisions regarding the compounds subject to limitation are necessary.
摘要：
废气排放,这些都是全球最常见的过早死亡原因之一，会导致细胞不可逆的变化，导致它们的损伤或退化。在这项研究中,在BAT-CELL室中暴露于从Euro6压缩点火发动机排放的废气后，观察到L929系细胞。模拟了真实的道路交通状况，考虑到以50km/h的速度行驶时的空气阻力，120公里/小时和怠速发动机。使用环境扫描电子显微镜进行细胞的形态分析。据观察，柴油废气会引起炎症，可以诱导细胞凋亡或导致坏死细胞死亡。车辆废气的影响可以抑制细胞增殖几乎三倍。此外，已经观察到细胞中炎症反应的速度与确定废气毒性的特定碳氢化合物的存在之间的相关性。研究表明，在120km/h的行驶速度下，排放的废气的毒性最高。为了减少废气排放的有害影响，生态替代品和补充有关受限制化合物的法律规定是必要的。
