METHODS: PCOS patients treated in a tertiary hospital in Anhui Province from October 2021 to October 2022 were selected as the case group, and non-PCOS patients treated in the hospital during the same period were selected as the control group. A total of 262 subjects were included in the study, 131 were included in the case group and 131 in the control group. A semi-quantitative dietary frequency questionnaire was used to investigate the dietary intake in the past year, and the daily intake of various fatty acids and the ratio of fatty acid energy supply were calculated according to the food intake. Logistic regression analysis was used to investigate the association between dietary fat intake and the risk of PCOS.
RESULTS: The dietary intakes of total fat, fatty acid, saturated fatty acid and monounsaturated fatty acid in PCOS patients were higher than those in control group(P>0.05), and there was statistical significance in daily intakes of eicosapentaenoic acid between two groups(P<0.05). After adjusting for confounding factors such as long-term residence, occupation, family per capita monthly income, menstrual cycle regularity, menstrual volume, and weight loss experience, Logistic regression analysis showed that the ratio of fat supply to energy was positively correlated with the risk of PCOS(OR=1.622, 95%CI 1.237-2.127). The energy supply ratio of monosaturated fatty acids(OR=0.597, 95%CI 0.373-0.955) and polyunsaturated fatty acids(OR=0.585, 95%CI 0.372-0.921) were negatively correlated with the risk of PCOS(P<0.05).
CONCLUSIONS: The energy supply ratio of fat was positively correlated with the risk of PCOS, while the energy supply ratio of monosaturated fatty acids and the energy supply ratio of polyunsaturated fatty acids were negatively correlated with the risk of PCOS.
方法:选取2021年10月至2022年10月安徽省某三级医院收治的PCOS患者作为病例组,选取同期住院的非PCOS患者作为对照组。共有262名受试者被纳入研究,病例组131例,对照组131例。采用半定量膳食频率问卷对过去一年的膳食摄入量进行调查,并根据食物摄入量计算各种脂肪酸的每日摄入量和脂肪酸能量供应比。采用Logistic回归分析探讨膳食脂肪摄入与PCOS发病风险的关系。
结果:总脂肪的膳食摄入量,脂肪酸,PCOS患者饱和脂肪酸和单不饱和脂肪酸高于对照组(P>0.05),两组二十碳五烯酸日摄入量比较差异有统计学意义(P<0.05)。在调整了长期居住等混杂因素后,职业,家庭人均月收入,月经周期规律性,月经量,和减肥经验,Logistic回归分析显示,脂肪供应与能量之比与PCOS风险呈正相关(OR=1.622,95CI1.237~2.127)。单饱和脂肪酸(OR=0.597,95CI0.373-0.955)和多不饱和脂肪酸(OR=0.585,95CI0.372-0.921)的能量供应比与PCOS风险呈负相关(P&lt;0.05)。
结论:脂肪能量供应比与PCOS风险呈正相关,单饱和脂肪酸的能量供应比和多不饱和脂肪酸的能量供应比与PCOS的风险呈负相关。