Abstract：
Driven by escalating environmental concerns, synthetic chemistry faces an urgent need for a green revolution. Green chemistry, with its focus on low environmental impacting chemicals and minimized waste production, emerges as a powerful tool in addressing this challenge. Metrics such as the E-factor guide the design of environmentally friendly strategies for chemical processes by quantifying the waste generated in obtaining target products, thus enabling interventions to minimize it. Phthalocyanines (Pcs), versatile molecules with exceptional physical and chemical properties, hold immense potential for technological applications. This review aims to bridge the gap between green chemistry and phthalocyanine synthesis by collecting the main examples of environmentally sustainable syntheses documented in the literature. The calculation of the E-factor of a selection of them provides insights on how crucial it is to evaluate a synthetic process in its entirety. This approach allows for a better evaluation of the actual sustainability of the phthalocyanine synthetic process and indicates possible strategies to improve it.
摘要：
在不断升级的环境问题的推动下，合成化学迫切需要一场绿色革命。绿色化学,专注于低环境影响化学品和最大限度地减少废物产生，成为应对这一挑战的强大工具。电子因子等指标通过量化获得目标产品产生的废物来指导化学过程的环保策略的设计，从而使干预措施最小化。酞菁（Pcs），具有特殊物理和化学性质的多功能分子，拥有巨大的技术应用潜力。这篇综述旨在通过收集文献中记录的环境可持续合成的主要例子来弥合绿色化学与酞菁合成之间的差距。选择它们的E因子的计算提供了对整体评估合成过程的重要性的见解。这种方法可以更好地评估酞菁合成过程的实际可持续性，并指出可能的改进策略。
