METHODS: This is a retrospective study of all surgically treated MPT patients in a multidisciplinary head and neck cancer (HNC) survivorship clinic (2017-2023). PROMs included University of Washington Quality of Life Questionnaire (UW-QOL), Eating Assessment Tool (EAT-10), Patient Health Questionnaire (PHQ-8), Generalized Anxiety Disorder (GAD-7), Neck Disability Index (NDI), and Insomnia Severity Index. Multivariable regression analysis was used to investigate clinical predictors associated with PROMs.
RESULTS: In 62 MPT patients, the prevalence of clinically relevant dysphagia symptoms (EAT-10), elevated symptoms of depression (PHQ-8), moderate/severe symptoms of anxiety (GAD-7), moderate/severe neck pain with activities of daily living (NDI), and moderate/severe symptoms of insomnia at last follow-up was 32.3%, 15.5%, 7.1%, 17.7%, and 7.2%, respectively. Nonparametric one-sided test revealed that patients treated with adjuvant CRT had significantly worse physical QOL, social-emotional QOL, and swallowing scores than patients treated with surgery alone (p = 0.01, p = 0.02, p = 0.03, respectively); that patients treated with surgery and adjuvant RT had significantly worse physical QOL and social-emotional QOL than patients treated with surgery alone (p < 0.01, p = 0.01, respectively) and that patients treated with surgery and adjuvant CRT had significantly worse swallowing and neck pain than patients treated with surgery and adjuvant RT (p = 0.03, p = 0.05, respectively).
CONCLUSIONS: In patients with surgically treated MPT, adjuvant CRT and RT were associated with worse PROMs.
METHODS: 4 Laryngoscope, 2024.
方法:这是一项对多学科头颈癌(HNC)生存诊所(2017-2023年)中所有手术治疗的MPT患者的回顾性研究。PROM包括华盛顿大学生活质量问卷(UW-QOL),饮食评估工具(EAT-10),患者健康问卷(PHQ-8),广义焦虑症(GAD-7),颈部残疾指数(NDI)失眠严重程度指数。多变量回归分析用于研究与PROMs相关的临床预测因子。
结果:在62例MPT患者中,临床相关吞咽困难症状(EAT-10)的患病率,抑郁症状(PHQ-8),中度/重度焦虑症状(GAD-7),中度/重度颈部疼痛与日常生活活动(NDI),最后随访时失眠的中/重度症状为32.3%,15.5%,7.1%,17.7%,和7.2%,分别。非参数单侧检验显示,接受辅助CRT治疗的患者的身体生活质量明显较差,社会情绪QOL,与单纯手术治疗的患者相比(p=0.01,p=0.02,p=0.03);与单纯手术治疗的患者相比,接受手术治疗和辅助放疗的患者的身体生活质量和社会情绪生活质量显著更差(分别为p<0.01,p=0.01),接受手术和辅助CRT治疗的患者的吞咽和颈部疼痛显著更差(分别为p=0.03,p=0.05)。
结论:在接受手术治疗的MPT患者中,辅助CRT和RT与较差的PROMs相关。
方法:4喉镜,2024.