目的:采用Meta分析评价超声引导下射频消融联合肝动脉栓塞化疗治疗肝癌的疗效和安全性。
方法:在PubMed数据库中搜索了超声引导下射频消融联合肝动脉栓塞化疗治疗肝细胞癌的随机对照研究,Embase,科克伦图书馆,科学网,搜索截止日期为2024年3月14日。使用Stata15.0分析数据。
结果:最终纳入了涉及520名个体的6项随机对照研究,荟萃分析结果显示,超声引导下射频消融联合TACE可提高客观缓解率[RR=1.52,95CI(1.28,1.81)],提高疾病控制率[RR=1.15,95CI(1.06,1.24)],生存率[RR=1.34,95CI(1.19,1.51)]未增加不良反应[RR=1.34,95CI(1.00,1.79)]。
结论:根据当前研究的结果,超声引导下射频消融联合TACE可提高客观缓解率,疾病控制率,并且没有增加肝细胞癌患者的不良事件。
OBJECTIVE: Meta-analysis was used to assess the efficacy and safety of ultrasound-guided radiofrequency ablation combined with transhepatic artery embolization chemotherapy for hepatocellular carcinoma.
METHODS: Randomized controlled studies on ultrasound-guided radiofrequency ablation combined with transhepatic artery embolization chemotherapy for hepatocellular carcinoma were searched in the databases of PubMed, Embase, Cochrane library, web of science with a search deadline of March 14, 2024. Data were analyzed using Stata 15.0.
RESULTS: Six randomized controlled studies involving 520 individuals were finally included, the results of meta-analysis showed that ultrasound-guided radiofrequency ablation combined with TACE can improve objective response rate [RR = 1.52, 95%CI (1.28, 1.81)], improve disease control rate [RR = 1.15, 95%CI (1.06, 1.24)], The survival rate [RR = 1.34, 95%CI (1.19,1.51)] did not increase adverse reactions [RR = 1.34, 95%CI (1.00,1.79)].
CONCLUSIONS: Based on the findings of the current study, ultrasound-guided radiofrequency ablation combined with TACE was found to improve the objective remission rate, disease control rate, and did not increase adverse events in patients with hepatocellular carcinoma.