{Reference Type}: Journal Article
{Title}: Quality of Life Outcomes for Parotid Malignancies.
{Author}: Tang A;Li J;Scheff N;Johnson JT;Contrera KJ;Nilsen ML;
{Journal}: Laryngoscope
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 4
{Factor}: 2.97
{DOI}: 10.1002/lary.31554
{Abstract}: <B>BACKGROUND: </B>This study describes patient-reported outcome measures (PROMs) and associated factors in patients who underwent surgery for malignant parotid tumors (MPT).<BR><B>METHODS: </B>This is a retrospective study of all surgically treated MPT patients in a multidisciplinary head and neck cancer (HNC) survivorship clinic (2017-2023). PROMs included University of Washington Quality of Life Questionnaire (UW-QOL), Eating Assessment Tool (EAT-10), Patient Health Questionnaire (PHQ-8), Generalized Anxiety Disorder (GAD-7), Neck Disability Index (NDI), and Insomnia Severity Index. Multivariable regression analysis was used to investigate clinical predictors associated with PROMs.<BR><B>RESULTS: </B>In 62 MPT patients, the prevalence of clinically relevant dysphagia symptoms (EAT-10), elevated symptoms of depression (PHQ-8), moderate/severe symptoms of anxiety (GAD-7), moderate/severe neck pain with activities of daily living (NDI), and moderate/severe symptoms of insomnia at last follow-up was 32.3%, 15.5%, 7.1%, 17.7%, and 7.2%, respectively. Nonparametric one-sided test revealed that patients treated with adjuvant CRT had significantly worse physical QOL, social-emotional QOL, and swallowing scores than patients treated with surgery alone (p = 0.01, p = 0.02, p = 0.03, respectively); that patients treated with surgery and adjuvant RT had significantly worse physical QOL and social-emotional QOL than patients treated with surgery alone (p < 0.01, p = 0.01, respectively) and that patients treated with surgery and adjuvant CRT had significantly worse swallowing and neck pain than patients treated with surgery and adjuvant RT (p = 0.03, p = 0.05, respectively).<BR><B>CONCLUSIONS: </B>In patients with surgically treated MPT, adjuvant CRT and RT were associated with worse PROMs.<BR><B>METHODS: </B>4 Laryngoscope, 2024.