PDF(Pubmed)
Abstract：
Data on the association between social isolation, loneliness, and risk of incident coronary heart disease (CVD) are conflicting. The objective of this study is to determine the relationship between social isolation and loneliness, and the risk of developing cardiovascular disease (CVD) in middle age and elderly using meta-analysis. The purpose of the bibliometric analysis is to systematically evaluate the existing literature on the relationship between social isolation, loneliness, and the risk of developing cardiovascular disease (CVD) in middle-aged and elderly individuals. A comprehensive search through four electronic databases (MEDLINE, Google Scholar, Scopus, and Web of Science) was conducted for published articles that determined the association between social isolation and/or loneliness and the risk of developing coronary heart disease from June 2015 to May 2023. Two independent reviewers reviewed the titles and abstracts of the records. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline to conduct the systematic review and meta-analysis. Data for the bibliometric analysis was obtained from the Scopus database and analyzed using VOSviewer and Bibliometrix applications. Six studies involving 104,511 patients were included in the final qualitative review and meta-analysis after screening the records. The prevalence of loneliness ranged from 5 to 65.3%, and social isolation ranged from 2 to 56.5%. A total of 5073 cardiovascular events were recorded after follow-up, ranging between 4 and 13 years. Poor social relationships were associated with a 16% increase in the risk of incident CVD (Hazard Ratio of new CVD when comparing high versus low loneliness or social isolation was 1.16 (95% Confidence Interval (CI) 1.10-1.22). The bibliometric analysis shows a rapidly growing field (9.77% annual growth) with common collaboration (6.37 co-authors/document, 26.53% international). The US leads research output, followed by the UK and Australia. Top institutions include University College London, Inserm, and the University of Glasgow. Research focuses on \"elderly,\" \"cardiovascular disease,\" and \"psychosocial stress,\" with recent trends in \"mental health,\" \"social determinants,\" and \"COVID-19\". Social isolation and loneliness increase the risk of and worsen outcomes in incident cardiovascular diseases. However, the observed effect estimate is small, and this may be attributable to residual confounding from incomplete measurement of potentially confounding or mediating factors. The results of the bibliometric analysis highlight the multidimensional nature of CVD research, covering factors such as social, psychological, and environmental determinants, as well as their interplay with various demographic and health-related variables.
摘要：
关于社会孤立之间关联的数据，孤独,和意外发生冠心病（CVD）的风险是相互矛盾的。这项研究的目的是确定社会孤立和孤独之间的关系，使用荟萃分析的中老年人患心血管疾病（CVD）的风险。文献计量分析的目的是系统地评估现有文献中关于社会隔离、孤独,以及中老年人患心血管疾病（CVD）的风险。通过四个电子数据库(MEDLINE，谷歌学者，Scopus,和WebofScience）对已发表的文章进行了研究，这些文章确定了2015年6月至2023年5月社会孤立和/或孤独与患冠心病风险之间的关系。两名独立审稿人审查了记录的标题和摘要。我们遵循系统评价和荟萃分析的首选报告项目指南进行系统评价和荟萃分析。从Scopus数据库获得用于文献计量分析的数据，并使用VOSviewer和Bibliometrix应用程序进行分析。在筛选记录后，将涉及104,511名患者的6项研究纳入最终的定性审查和荟萃分析。孤独感的患病率为5-65.3%,社会隔离率为2%至56.5%。随访后共记录5073例心血管事件，在4到13年之间。不良的社会关系与心血管事件风险增加16％相关（比较高与低孤独或社会隔离时，新CVD的危险比为1.16（95％置信区间（CI）1.10-1.22）。文献计量分析显示了一个快速增长的领域(9.77%的年增长率)与共同合作(6.37合著者/文档，26.53%国际）。美国领先的研究成果，其次是英国和澳大利亚。顶尖机构包括伦敦大学学院，插入,和格拉斯哥大学。研究的重点是“老年人，心血管疾病，“和”心理社会压力，“随着心理健康的最新趋势，社会决定因素，\"和\"COVID-19\"。社会隔离和孤独会增加心血管疾病的风险并恶化结果。然而,观察到的效应估计很小，这可能归因于对潜在混杂或中介因素的不完全测量造成的残余混杂。文献计量分析的结果突出了CVD研究的多维性质，涵盖社会等因素，心理,和环境决定因素，以及它们与各种人口和健康相关变量的相互作用。
