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Abstract：
RNA biology has revolutionized cancer understanding and treatment, especially in endocrine-related malignancies. This editorial highlights RNA\'s crucial role in cancer progression, emphasizing its influence on tumor heterogeneity and behavior. Processes like alternative splicing and noncoding RNA regulation shape cancer biology, with microRNAs, long noncoding RNAs, and circular RNAs orchestrating gene expression dynamics. Aberrant RNA signatures hold promise as diagnostic and prognostic biomarkers in endocrine-related cancers. Recent findings, such as aberrant PI3Kδ splice isoforms and epithelial-mesenchymal transition-related lncRNA signatures, unveil potential therapeutic targets for personalized treatments. Insights into m6A-associated lncRNA prognostic models and the function of lncRNA LINC00659 in gastric cancer represents ongoing research in this field. As understanding of RNA\'s role in cancer expands, personalized therapies offer transformative potential in managing endocrine-related malignancies. This signifies a significant stride towards precision oncology, fostering innovation for more effective cancer care.
摘要：
RNA生物学彻底改变了对癌症的理解和治疗，尤其是内分泌相关恶性肿瘤。这篇社论强调了RNA在癌症进展中的关键作用，强调其对肿瘤异质性和行为的影响。选择性剪接和非编码RNA调控等过程塑造了癌症生物学，与microRNA，长链非编码RNA，和环状RNA协调基因表达动力学。异常RNA特征有望作为内分泌相关癌症的诊断和预后生物标志物。最近的发现,如异常的PI3Kδ剪接亚型和上皮-间质转化相关的lncRNA特征，揭示个性化治疗的潜在治疗目标。对m6A相关lncRNA预后模型和lncRNALINC00659在胃癌中的功能的见解代表了该领域正在进行的研究。随着对RNA在癌症中的作用的理解的扩展，个性化治疗在管理内分泌相关恶性肿瘤方面提供了转化潜力.这标志着精确肿瘤学的重大进步，促进更有效的癌症治疗创新。
