PDF(Pubmed)
Abstract：
Lumbar sympathetic ganglion neurolysis (LSGN) has been used for long-term pain relief in patients with complex regional pain syndrome (CRPS). However, the actual effect duration of LSGN has not been accurately measured. This prospective observational study measured the effect duration of LSGN in CRPS patients and investigated the relationship between temperature change and pain relief. After performing LSGN, the skin temperatures of both the maximum pain site and the plantar area in the affected and unaffected limbs were measured by infrared thermography, and pain intensity was assessed before and at 2 weeks, 1 month, and 3 months. The median time to return to baseline temperature was calculated using survival analysis. The skin temperature increased significantly at all-time points relative to baseline in both regions (maximum pain site: 1.4 °C ± 1.0 °C, plantar region: 1.28 °C ± 0.8 °C, all P < 0.001). The median time to return to baseline temperature was 12 weeks (95% confidence interval [CI] 7.7-16.3) at the maximum pain site and 12 weeks (95% CI 9.4-14.6) at the plantar area. Pain intensity decreased significantly relative to baseline, at all-time points after LSGN. In conclusion, the median duration of the LSGN is estimated to be 12 weeks.
摘要：
腰交感神经节神经松解术（LSGN）已用于复杂区域疼痛综合征（CRPS）患者的长期疼痛缓解。然而,LSGN的实际效果持续时间尚未得到准确测量。这项前瞻性观察研究测量了LSGN在CRPS患者中的作用持续时间，并研究了温度变化与疼痛缓解之间的关系。执行LSGN后，用红外热成像法测定患肢和未患肢最大疼痛部位和足底区域的皮肤温度，并在2周前和2周时评估疼痛强度，1个月,和3个月。使用生存分析计算返回基线温度的中值时间。在两个区域中，相对于基线，皮肤温度在所有时间点都显着增加（最大疼痛部位：1.4°C±1.0°C，足底区域：1.28°C±0.8°C，所有P<0.001)。最大疼痛部位恢复至基线温度的中位时间为12周（95％置信区间[CI]7.7-16.3），足底区域为12周（95％CI9.4-14.6）。疼痛强度相对于基线显著下降，在LSGN之后的所有时间点。总之,LSGN的中位持续时间估计为12周.
