Abstract：
Environmental exposures may have endocrine disruptor (ED) effects, e.g., a role for halogenated hydrocarbon chlorobenzenes in increasing vasopressin (AVP), oxytocin (OT) secretion and, in association, anxiety and aggression in male rats has been shown. Our aim is to investigate whether 1,2,4-trichlorobenzenehexachlorobenzene= 1:1 (mClB) treatment of female rats also shows ED effects and reproductive biology differences, and whether AVP may have a mediator role in this? Female Wistar rats were treated (0.1; 1.0; 10.0 μg/bwkg/day) with mClB (by gastrictube) and then 30; 60; 90 days after treatment anxiety (open field test) and aggressive (resident intruder test) behaviors AVP, OT concentrations from blood plasma samples were detected by radioimmunoassay on 30; 60; 90 days. Treated female rats were mated with untreated males. Mating success, number of newborn and maternal aggression on the neonates were monitored. Results showed that AVP, OT levels; and anxiety, aggressive behaviors; and mothers\' aggression towards their offspring increased significantly in relation to the duration and the dose of mClB treatment. But mating propensity and number of offspring decreased. Patterns of AVP, OT release and anxiety, aggression behaviors, and reproductive-related behaviors were correlated. Consistent with the literature, our studies confirmed the role of AVP and OT in different behavioral effects.
摘要：
环境暴露可能会产生内分泌干扰物(ED)效应，例如，卤代烃氯苯在增加血管加压素（AVP）中的作用，催产素（OT）分泌和，在协会中，已经显示出雄性大鼠的焦虑和攻击性。我们的目的是调查1,2,4-三氯苯六氯苯=1:1（mClB）治疗雌性大鼠是否也显示出ED效应和生殖生物学差异，以及AVP是否在其中具有中介作用？雌性Wistar大鼠用mClB治疗（0.1;1.0;10.0μg/bwkg/天）（通过gestertube），然后在治疗后30;60;90天，通过放射免疫分析法在30；60；90天检测血浆样品中的OT浓度。将处理的雌性大鼠与未处理的雄性交配。交配成功，监测新生儿和产妇对新生儿的攻击次数.结果表明，AVP，OT水平；和焦虑，攻击行为；母亲对后代的攻击性与mClB治疗的持续时间和剂量有关显著增加。但交配倾向和后代数量下降。AVP的模式,OT释放和焦虑，侵略行为，与生殖相关的行为有关。与文献一致，我们的研究证实了AVP和OT在不同行为效应中的作用.
