PDF(Pubmed)
Abstract：
Aim: Non-melanoma skin cancers are more common in people with inflammatory bowel disease. However, these tumors can rarely mimic a cutaneous manifestation of the disease, which delays diagnosis and clouds prognosis. Observation: A 35-year-old man with stenosing and fistulizing ileocolic Crohn\'s disease developed squamous cell carcinoma mimicking a groin fold abscess. After surgical drainage of the abscess, despite antibiotics and therapy combining azathioprine with infliximab, the abscess has recurred. Biopsies revealed a cutaneous squamous cell carcinoma. Palliative radiotherapy-chemotherapy was initiated, but the patient died after 3 months. Conclusion: This observation illustrates the increased risk of non-melanoma skin cancers in inflammatory bowel disease patients, particularly those exposed to thiopurines, and the value of diagnosing them at an early stage.
摘要：
目的：非黑色素瘤皮肤癌在炎症性肠病患者中更为常见。然而,这些肿瘤很少能模仿这种疾病的皮肤表现，这会延迟诊断和模糊预后。观察：一名35岁的男性患有狭窄和造瘘回肠结肠克罗恩病，发展为模仿腹股沟皱褶脓肿的鳞状细胞癌。脓肿手术引流后，尽管抗生素和硫唑嘌呤联合英夫利昔单抗治疗，脓肿复发了.活检显示皮肤鳞状细胞癌。开始姑息性放疗-化疗，但患者在3个月后死亡。结论：这一观察结果说明炎症性肠病患者非黑色素瘤皮肤癌的风险增加，特别是那些暴露于硫嘌呤的人，以及早期诊断的价值。
