PDF(Pubmed)
Abstract：
Vitamin D deficiency and insufficiency pose global public health challenges, yet research on serum vitamin D levels in the 0-17-year-old age group in southeastern China remains limited. This study aimed to fill this gap by investigating serum 25(OH)D levels in children in the region aged 0-17 years, contributing crucial data for understanding vitamin D nutritional status. Liquid chromatography‒mass spectrometry/mass spectrometry (LC‒MS/MS) technology was used. Vitamin D testing was integrated into routine diagnostic procedures for 11,116 children in Wujiang District, Suzhou City. Among the 0-17-year age group, comprising 6348 boys and 4768 girls, the prevalence of serum 25(OH)D deficiency and insufficiency was 21.4% and 31.0%, respectively. The median serum 25(OH)D concentration was 29.72 ng/mL (21.84-39.84 ng/mL) in boys compared to 28.48 ng/mL (20.65-39.23 ng/mL) in girls. Seasonal variations were observed, with median serum 25(OH)D concentrations of 29.02 ng/mL (20.73-39.72 ng/mL) in spring, 28.79 ng/mL (21.53-39.37 ng/mL) in summer, 30.12 ng/mL (22.00-39.70 ng/mL) in autumn, and 28.58 ng/mL (19.97-39.46 ng/mL) in winter. Statistically significant differences were noted in the serum 25(OH)D levels during autumn and winter. In conclusion, the rate of adequate vitamin D levels in local children was 47.5%, revealing a relatively high prevalence of vitamin D deficiency (21.4%) and insufficiency (31.0%), especially during the post-preschool period. Advocating for vitamin D supplementation in children is crucial for ensuring adequate vitamin D support.
摘要：
维生素D缺乏和不足构成全球公共卫生挑战，然而,对中国东南部0-17岁年龄组血清维生素D水平的研究仍然有限.这项研究旨在通过调查该地区0-17岁儿童的血清25（OH）D水平来填补这一空白。为了解维生素D营养状况提供重要数据。采用液相色谱-质谱/质谱(LC-MS/MS)技术。吴江区11116名儿童的维生素D检测被纳入常规诊断程序，苏州市。在0-17岁年龄组中，包括6348名男孩和4768名女孩，血清25（OH）D缺乏和不足的患病率分别为21.4％和31.0％，分别。男孩的血清25（OH）D浓度中位数为29.72ng/mL（21.84-39.84ng/mL），而女孩为28.48ng/mL（20.65-39.23ng/mL）。观察到季节性变化，春季血清25（OH）D浓度中位数为29.02ng/mL（20.73-39.72ng/mL），夏季28.79ng/mL（21.53-39.37ng/mL），秋季30.12ng/mL（22.00-39.70ng/mL），冬季为28.58ng/mL（19.97-39.46ng/mL）。在秋季和冬季，血清25（OH）D水平存在统计学上的显着差异。总之,当地儿童维生素D水平充足的比率为47.5%，维生素D缺乏(21.4%)和维生素D不足(31.0%)的患病率相对较高，尤其是在后学前时期。倡导儿童补充维生素D对于确保足够的维生素D支持至关重要。
