Abstract：
In Italy, the measles elimination target has not yet been reached despite a significant reduction in cases. A multicenter study was conducted to estimate the prevalence of anti-measles (MV) IgG antibodies in the Italian population by age, sex and geographical area. To determine the level of MV-specific antibodies in sera, the immunoenzymatic assay ELISA was used (Enzygnost Anti-VZV/IgG, Siemens Healthcare Diagnostic Products GmbH, Germany). Overall, 3746 serum samples collected in the years 2019-20 from healthy subjects aged 6-64 years residing in 13 Italian regions. The overall seroprevalence of anti-MV IgG was 91.2 % (90.6 % male, 91.7 % female). Significantly higher seroprevalence values (p < 0.05) were recorded for the extreme age groups of the study population (6-9 years: 94.2 %; 40-64 years: 97.6 %). Subjects 20-39 and 40-64 years old had significantly higher antibody titers suggesting a protection against measles mainly derived from natural infection. Seroprevalence was significantly higher in the South (93.2 %) than in the Northern-Central Italy (88.9 %). The results indicate an increase in the overall seroprevalence data compared to previous investigations. However, further efforts must be made to implement and maintain high measles vaccination coverage to avoid the risk of future epidemic outbreaks.
摘要：
在意大利,尽管病例大幅减少，但消除麻疹的目标尚未实现。进行了一项多中心研究，以按年龄估算意大利人群中抗麻疹（MV）IgG抗体的患病率，性别和地理区域。为了确定血清中MV特异性抗体的水平，使用免疫酶联免疫吸附试验(EnzygnostAnti-VZV/IgG，西门子医疗诊断产品有限公司,德国)。总的来说,在2019-20年期间，从居住在意大利13个地区的6-64岁健康受试者中收集了3746份血清样本。抗MVIgG的总体血清阳性率为91.2％（男性90.6％，91.7%女性)。研究人群的极端年龄组(6-9岁:94.2%;40-64岁:97.6%)记录到显著更高的血清阳性率值(p<0.05)。20-39岁和40-64岁的受试者具有明显更高的抗体滴度，表明对主要来自自然感染的麻疹具有保护作用。南部的血清阳性率（93.2％）明显高于意大利中北部的血清阳性率（88.9％）。结果表明，与以前的研究相比，总体血清阳性率数据有所增加。然而,必须进一步努力实施和保持麻疹疫苗的高覆盖率，以避免未来疫情爆发的风险。
