Abstract：
Gliomas are the most common primary malignant tumors of the brain, accounting for about 80% of all central nervous system malignancies. With the development of molecular biology, the molecular phenotypes of gliomas have been shown to be closely related to the process of diagnosis and treatment. The molecular phenotype of glioma also plays an important role in guiding treatment plans and evaluating treatment effects and prognosis. However, due to the heterogeneity of the tumors and the trauma associated with the surgical removal of tumor tissue, the application of molecular phenotyping in glioma is limited. With the development of imaging technology, functional magnetic resonance imaging (MRI) can provide structural and function information about tumors in a noninvasive and radiation-free manner. MRI is very important for the diagnosis of intracranial lesions. In recent years, with the development of the technology for tumor molecular diagnosis and imaging, the use of molecular phenotype information and imaging procedures to evaluate the treatment outcome of tumors has become a hot topic. By reviewing the related literature on glioma treatment and molecular typing that has been published in the past 20 years, and referring to the latest 2020 NCCN treatment guidelines, summarizing the imaging characteristic and sensitivity of radiotherapy and chemotherapy of different molecular phenotypes of glioma. In this article, we briefly review the imaging characteristics of different molecular phenotypes in gliomas and their relationship with radiosensitivity and chemosensitivity of gliomas.
摘要：
胶质瘤是最常见的原发性脑恶性肿瘤，约占所有中枢神经系统恶性肿瘤的80％。随着分子生物学的发展,胶质瘤的分子表型已被证明与诊断和治疗过程密切相关。脑胶质瘤的分子表型在指导治疗方案、评估治疗效果和预后方面也起着重要作用。然而,由于肿瘤的异质性和与手术切除肿瘤组织相关的创伤，分子表型分析在胶质瘤中的应用是有限的。随着成像技术的发展,功能磁共振成像(MRI)能够以非侵入性和无辐射的方式提供肿瘤的结构和功能信息。MRI对颅内病变的诊断非常重要。近年来,随着肿瘤分子诊断和影像学技术的发展,使用分子表型信息和影像学程序来评估肿瘤的治疗结果已成为热点。通过回顾近20年来发表的关于胶质瘤治疗和分子分型的相关文献,并参考最新的2020年NCCN治疗指南，总结不同分子表型脑胶质瘤的影像学特点及放化疗敏感性。在这篇文章中,本文简要综述了脑胶质瘤不同分子表型的影像学特点及其与脑胶质瘤放射敏感性和化疗敏感性的关系。
