PDF(Pubmed)
Abstract：
BACKGROUND: Multiple sclerosis (MS) is an immune-mediated demyelinating disease with a significant burden of neuropsychiatric sequelae. These symptoms, including depression and anxiety, are predictors of morbidity and mortality in people with MS. Despite a high prevalence of obsessive-compulsive disorder in MS, potentially shared pathophysiological mechanisms and overlap in possible treatments, no review has specifically examined the clinical dimensions of people with obsessive-compulsive and related disorders (OCRD) and MS. In this scoping review, we aim to map the available knowledge on the clinical dimensions of people with co-occurring OCRD and MS. Understanding the characteristics of this population in greater detail will inform more patient-centred care and create a framework for future studies.
METHODS: We developed a search strategy to identify all articles that include people with co-occurring OCRD and MS. The search strategy (extending to the grey literature) was applied to MEDLINE, Embase, PsycINFO, Cochrane Central Register of Controlled Trials, CINAHL, Web of Science and ProQuest Dissertations & Theses. Records will undergo title and abstract screening by two independent reviewers. Articles meeting inclusion criteria based on title and abstract screening will go on to full-text review by the two independent reviewers. After reaching a consensus about articles for inclusion in the final review, data will be extracted using a standardised extraction form. The extracted data will include clinical characteristics of patients such as age, gender, medication use and severity of MS, among others.
BACKGROUND: This scoping review does not require research ethics approval. Results will be shared at national and/or international conferences, in a peer-reviewed journal publication, in a plain language summary and in a webinar for the general public.
METHODS: We developed a search strategy to identify all articles that include people with co-occurring OCRD and MS. The search strategy (extending to the grey literature) was applied to MEDLINE, Embase, PsycINFO, Cochrane Central Register of Controlled Trials, CINAHL, Web of Science and ProQuest Dissertations & Theses. Records will undergo title and abstract screening by two independent reviewers. Articles meeting inclusion criteria based on title and abstract screening will go on to full-text review by the two independent reviewers. After reaching a consensus about articles for inclusion in the final review, data will be extracted using a standardised extraction form. The extracted data will include clinical characteristics of patients such as age, gender, medication use and severity of MS, among others.
BACKGROUND: This scoping review does not require research ethics approval. Results will be shared at national and/or international conferences, in a peer-reviewed journal publication, in a plain language summary and in a webinar for the general public.
摘要：
背景：多发性硬化症（MS）是一种免疫介导的脱髓鞘疾病，具有严重的神经精神后遗症负担。这些症状,包括抑郁和焦虑,是MS患者发病率和死亡率的预测因子。尽管强迫症在MS中患病率很高，潜在的共同病理生理机制和可能的治疗重叠，没有专门审查强迫症及相关疾病（OCRD）和MS患者的临床维度。在这次范围审查中，我们的目标是将可用知识映射到同时发生OCRD和MS的患者的临床维度上。更详细地了解该人群的特征将为更多以患者为中心的护理提供信息，并为未来的研究创建框架。
方法：我们开发了一种搜索策略来识别所有包含OCRD和MS患者的文章。搜索策略(延伸到灰色文献)应用于MEDLINE，Embase,PsycINFO,Cochrane中央控制试验登记册,CINAHL,WebofScienceandProQuest学位论文和论文。记录将由两名独立审稿人进行标题和摘要筛选。符合基于标题和摘要筛选的纳入标准的文章将继续由两名独立审稿人进行全文审查。在就纳入最终审查的条款达成共识后，将使用标准化的提取表单提取数据。提取的数据将包括患者的临床特征，如年龄，性别,药物使用和MS的严重程度，在其他人中。
背景：本范围审查不需要研究伦理批准。结果将在国家和/或国际会议上分享，在同行评审的期刊出版物中，在通俗易懂的语言摘要和面向公众的网络研讨会中。
方法：我们开发了一种搜索策略来识别所有包含OCRD和MS患者的文章。搜索策略(延伸到灰色文献)应用于MEDLINE，Embase,PsycINFO,Cochrane中央控制试验登记册,CINAHL,WebofScienceandProQuest学位论文和论文。记录将由两名独立审稿人进行标题和摘要筛选。符合基于标题和摘要筛选的纳入标准的文章将继续由两名独立审稿人进行全文审查。在就纳入最终审查的条款达成共识后，将使用标准化的提取表单提取数据。提取的数据将包括患者的临床特征，如年龄，性别,药物使用和MS的严重程度，在其他人中。
背景：本范围审查不需要研究伦理批准。结果将在国家和/或国际会议上分享，在同行评审的期刊出版物中，在通俗易懂的语言摘要和面向公众的网络研讨会中。
