Abstract：
Aging, a complex biological process, plays key roles the development of multiple disorders referred as aging-related diseases involving cardiovascular diseases, stroke, neurodegenerative diseases, cancers, lipid metabolism-related diseases. ADP-ribosylation is a reversible modification onto proteins and nucleic acids to alter their structures and/or functions. Growing evidence support the importance of ADP-ribosylation and ADP-ribosylation-associated enzymes in aging and age-related diseases. In this review, we summarized ADP-ribosylation-associated proteins including ADP-ribosyl transferases, the ADP-ribosyl hydrolyses and ADP-ribose binding domains. Furthermore, we outlined the latest knowledge about regulation of ADP-ribosylation in the pathogenesis and progression of main aging-related diseases, organism aging and cellular senescence, and we also speculated the underlying mechanisms to better disclose this novel molecular network. Moreover, we discussed current issues and provided an outlook for future research, aiming to revealing the unknown bio-properties of ADP-ribosylation, and establishing a novel therapeutic perspective in aging-related diseases and health aging via targeting ADP-ribosylation.
摘要：
衰老,一个复杂的生物过程，在多种疾病的发展中起着关键作用，这些疾病被称为涉及心血管疾病的衰老相关疾病，中风,神经退行性疾病，癌症,脂质代谢相关疾病。ADP-核糖基化是对蛋白质和核酸的可逆修饰以改变其结构和/或功能。越来越多的证据支持ADP-核糖基化和ADP-核糖基化相关酶在衰老和年龄相关疾病中的重要性。在这次审查中,我们总结了ADP-核糖基化相关蛋白，包括ADP-核糖基转移酶，ADP-核糖基水解和ADP-核糖结合域。此外，我们概述了ADP核糖基化在主要衰老相关疾病的发病机制和进展中的最新知识，生物体衰老和细胞衰老，我们还推测了更好地揭示这种新型分子网络的潜在机制。此外，我们讨论了当前的问题，并对未来的研究进行了展望，旨在揭示ADP核糖基化的未知生物特性，并通过靶向ADP-核糖基化在衰老相关疾病和健康衰老中建立了新的治疗观点。
